Article (Scientific journals)
Expression of the zinc finger Egr1 gene during zebrafish embryonic development
Close, Renaud; Toro, Sabrina; Martial, Joseph et al.
2002In Mechanisms of Development, 118 (1-2), p. 269-72
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Keywords :
Animals; Brain/embryology/metabolism; Central Nervous System/embryology; DNA, Complementary/metabolism; DNA-Binding Proteins/*biosynthesis/*genetics; *Gene Expression Regulation, Developmental; In Situ Hybridization; RNA, Messenger/metabolism; Retina/embryology; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transcription Factors/*biosynthesis/*genetics; Zebrafish; Zinc Fingers
Abstract :
[en] Egr1 is a highly conserved zinc finger protein which plays important roles in many aspects of vertebrate development and in the adult. The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization. Egr1 mRNA is first detected in adaxial cells in the presomitic mesoderm between 11 and 20 h post-fertilization (hpf), spanning the 4-24 somite stages. Later, Egr1 expression is observed only in specific brain areas, starting at 21 hpf and subsequently increasing in distinct domains of the central nervous system, e.g. in the telencephalon, diencephalon and hypothalamus. Between 24 and 48 hpf, Egr1 is expressed in specific domains of the hypothalamus, mesencephalon, tegmentum, pharynx, retina, otic vesicle and heart.
Research Center/Unit :
AFFISH-RC - Applied and Fundamental FISH Research Center - ULiège
Giga-Development and Stem Cells - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Close, Renaud
Toro, Sabrina
Martial, Joseph ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Muller, Marc  ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Language :
English
Title :
Expression of the zinc finger Egr1 gene during zebrafish embryonic development
Publication date :
2002
Journal title :
Mechanisms of Development
ISSN :
0925-4773
eISSN :
1872-6356
Publisher :
Elsevier, Limerick, Ireland
Volume :
118
Issue :
1-2
Pages :
269-72
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 May 2009

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