Article (Scientific journals)
TLR-4, IL-1R and TNF-R signaling to NF-kB: variations on a common theme
Verstrepen, L.; Bekaert, T.; Chau, Tieu-Lan et al.
2008In Cellular and Molecular Life Sciences, 65, p. 2964-2978
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Keywords :
NF kappa B; TNF; IL-1
Abstract :
[en] Toll-like receptors (TLRs) as well as the receptors for tumor necrosis factor (TNF-R) and interleukin-1 (IL-1R) play an important role in innate immunity by regulating the activity of distinct transcription factors such as nuclear factor-kappaB (NF-kappaB). TLR, IL-1R and TNF-R signaling to NF-kappaB converge on a common IkappaB kinase complex that phosphorylates the NF-kappaB inhibitory protein IkappaBalpha. However, upstream signaling components are in large part receptor-specific. Nevertheless, the principles of signaling are similar, involving the recruitment of specific adaptor proteins and the activation of kinase cascades in which protein-protein interactions are controlled by poly-ubiquitination. In this review, we will discuss our current knowledge of NF-kappaB signaling in response to TLR-4, TNF-R and IL-1R stimulation, with a special focus on the similarities and dissimilarities among these pathways.
Research center :
Giga-Signal Transduction - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Verstrepen, L.;  University of Ghent, VIB
Bekaert, T.;  University of Ghent, VIB
Chau, Tieu-Lan ;  ULg - Université de Liège
Tavernier, J.;  University of Ghent, VIB
Chariot, Alain ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Beyaert, Rudi;  University of Ghent, VIB
Language :
English
Title :
TLR-4, IL-1R and TNF-R signaling to NF-kB: variations on a common theme
Publication date :
2008
Journal title :
Cellular and Molecular Life Sciences
ISSN :
1420-682X
eISSN :
1420-9071
Publisher :
Springer Science & Business Media B.V., Basel, Switzerland
Volume :
65
Pages :
2964-2978
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 November 2008

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