TLR-4, IL-1R and TNF-R signaling to NF-kB: variations on a common theme

[en] Toll-like receptors (TLRs) as well as the receptors for tumor necrosis factor (TNF-R) and interleukin-1 (IL-1R) play an important role in innate immunity by regulating the activity of distinct transcription factors such as nuclear factor-kappaB (NF-kappaB). TLR, IL-1R and TNF-R signaling to NF-kappaB converge on a common IkappaB kinase complex that phosphorylates the NF-kappaB inhibitory protein IkappaBalpha. However, upstream signaling components are in large part receptor-specific. Nevertheless, the principles of signaling are similar, involving the recruitment of specific adaptor proteins and the activation of kinase cascades in which protein-protein interactions are controlled by poly-ubiquitination. In this review, we will discuss our current knowledge of NF-kappaB signaling in response to TLR-4, TNF-R and IL-1R stimulation, with a special focus on the similarities and dissimilarities among these pathways.

Research Center/Unit :

Giga-Signal Transduction - ULiège

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Verstrepen, L.; University of Ghent, VIB

Bekaert, T.; University of Ghent, VIB

Chau, Tieu-Lan ; ULg - Université de Liège

Tavernier, J.; University of Ghent, VIB

Chariot, Alain ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Beyaert, Rudi; University of Ghent, VIB

Language :

English

Title :

TLR-4, IL-1R and TNF-R signaling to NF-kB: variations on a common theme

Publication date :

2008

Journal title :

Cellular and Molecular Life Sciences

ISSN :

1420-682X

eISSN :

1420-9071

Publisher :

Springer Science & Business Media B.V., Basel, Switzerland

Volume :

Pages :

2964-2978

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 November 2008

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377

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373

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323

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406

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