Reference : TLR-4, IL-1R and TNF-R signaling to NF-kB: variations on a common theme
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
TLR-4, IL-1R and TNF-R signaling to NF-kB: variations on a common theme
Verstrepen, L. [University of Ghent, VIB]
Bekaert, T. [University of Ghent, VIB]
Chau, Tieu-Lan [University of Liege]
Tavernier, J. [University of Ghent, VIB]
Chariot, Alain mailto [Université de Liège - ULiège > Département de pharmacie > Chimie médicale >]
Beyaert, Rudi [University of Ghent, VIB]
Cellular and Molecular Life Sciences : CMLS
Springer Science & Business Media B.V.
Yes (verified by ORBi)
[en] NF kappa B ; TNF ; IL-1
[en] Toll-like receptors (TLRs) as well as the receptors for tumor necrosis factor (TNF-R) and interleukin-1 (IL-1R) play an important role in innate immunity by regulating the activity of distinct transcription factors such as nuclear factor-kappaB (NF-kappaB). TLR, IL-1R and TNF-R signaling to NF-kappaB converge on a common IkappaB kinase complex that phosphorylates the NF-kappaB inhibitory protein IkappaBalpha. However, upstream signaling components are in large part receptor-specific. Nevertheless, the principles of signaling are similar, involving the recruitment of specific adaptor proteins and the activation of kinase cascades in which protein-protein interactions are controlled by poly-ubiquitination. In this review, we will discuss our current knowledge of NF-kappaB signaling in response to TLR-4, TNF-R and IL-1R stimulation, with a special focus on the similarities and dissimilarities among these pathways.
Giga-Signal Transduction
Researchers ; Professionals ; Students

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