[en] Since 1998, routine [18F]FDG syntheses are being carried out by alkaline hydrolysis on a solid support, i.e. the labeled intermediate is trapped on a tC18 solid phase extraction cartridge, purified and finally hydrolyzed within the cartridge, at room temperature, using sodium hydroxide. The present study demonstrated that no epimerization of [18F]FDG to [18F]FDM occurs even when 12 N NaOH is used and when the hydrolysis time is extended up to 1 h. The alkaline hydrolysis on solid support appears to be a simple method leading to [18F]FDG with high purity.
Disciplines :
Energy Radiology, nuclear medicine & imaging Chemistry
Author, co-author :
Mosdzianowski, C.
Lemaire, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron
Simoens, F.
Aerts, Joël ; Université de Liège - ULiège > Centre de recherches du cyclotron
Morelle, J. L.
Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Language :
English
Title :
Epimerization study on [18F]FDG produced by an alkaline hydrolysis on solid support under stringent conditions
Publication date :
June 2002
Journal title :
Applied Radiation and Isotopes
ISSN :
0969-8043
Publisher :
Pergamon-Elsevier Science Ltd, Oxford, United Kingdom
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