Management of cases suffering from atypical myopathy: Interpretations of descriptive, epidemiological and pathophysiological findings. Part 2: Muscular, urinary, respiratory and hepatic care, and inflammatory/ infectious status
Van Galen, Gaby; Votion, Dominique
2013 • In Equine Veterinary Education, 25 (6), p. 308-314
[en] Atypical myopathy is highly fatal, but about a quarter of affected horses survive. This highlights the need for provision of supportive treatment for these patients. This review is a practical guideline for equine practitioners and includes suggestions for close monitoring of involved organ
systems and discusses options of supportive treatment
based on current knowledge of the condition. Part 2 covers
the muscular, urinary, respiratory and hepatic systems, and
the general inflammatory/infectious status of the case.
Research center :
FVM ULG
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Van Galen, Gaby ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Epidémiologie et analyse des risques appl. aux sc. vétér.
Votion, Dominique ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Language :
English
Title :
Management of cases suffering from atypical myopathy: Interpretations of descriptive, epidemiological and pathophysiological findings. Part 2: Muscular, urinary, respiratory and hepatic care, and inflammatory/ infectious status
Alternative titles :
[en] Gestion des cas souffrant de myopathie atypique: Interprétations des résultats des études épidémiologiques et physiopathologiques. Partie 2: fonctions musculaire, urinaire, respiratoire, hépatique, et inflammation.
Publication date :
2013
Journal title :
Equine Veterinary Education
ISSN :
0957-7734
eISSN :
2042-3292
Publisher :
Equine Veterinary Journal, Newmarket, United Kingdom
Barton, M.B. (2004) Disorders of the liver. In: Equine Internal Medicine, Eds: D.C. Sellon, S.M. Reed and W.M. Bayly, W.B. Saunders, Philadelphia. pp 951-994.
Brandt, K., Hinrichs, U., Glitz, F., Landes, E., Schulze, C., Deegen, E., Pohlenz, J. and Coenen, M. (1997) Atypical myoglobinuria in grazing horses. Pferdeheilkunde 13, 27-34.
Brezis, M., Agmon, Y. and Epstein, F.H. (1994) Determinants of intrarenal oxygenation. Effects of diuretics. Am. J. Physiol. 267, F1059-F1062.
Buchner, H.H.F. and Schildboeck, U. (2006) Physiotherapy applied to the horse: a review. Equine Vet. J. 38, 574-580.
Cassart, D., Baise, E., Cherel, Y., Delguste, C., Antoine, N., Votion, D., Amory, H., Rollin, F., Linden, A., Coignoul, F. and Desmecht, D. (2007) Morphological alterations in oxidative muscles and mitochondrial structure associated with equine atypical myopathy. Equine Vet. J. 39, 26-32.
Corley, K.T.T. and Stephen, J. (2008) The Equine Hospital Manual, Blackwell Publishing, Oxford.
Delguste, C., Cassart, D., Baise, E., Linden, A., Schwarzwald, C., Feige, K., Sandersen, C., Rollin, F. and Amory, H. (2002) Atypical myoglobinuria in grazing horses: an outbreak in Belgium. Ann. Med. Vet. 146, 235-247.
Donaldson, L. (2008a) Pain management in the hospitalised horse. In: The Equine Hospital Manual, Eds: K.T.T. Corley and J. Stephen, Blackwell Publishing, Oxford. pp 324-337.
Donaldson, L. (2008b) Standing sedation. In: The Equine Hospital Manual, Eds: K.T.T. Corley and J. Stephen, Blackwell Publishing, Oxford. pp 312-324.
Durando, M. (2008) Treating problems of the heart. In: The Equine Hospital Manual, Eds: K.T.T. Corley and J. Stephen, Blackwell Publishing, Oxford. pp 436-446.
Finno, C.J., Valberg, S.J., Wunschmann, A. and Murphy, M.J. (2006) Seasonal pasture myopathy in horses in the midwestern United States: 14 cases (1998-2005). J. Am. Vet. Med. Assoc. 229, 1134-1141.
Firshman, A.M. and Valberg, S.J. (2007) Factors affecting clinical assessment of insulin sensitivity in horses. Equine Vet. J. 39, 567-575.
Franck, T., Kohnen, S., Grulke, S., Neven, P., Goutman, Y., Peters, F., Pirotte, B., Deby-Dupont, G. and Serteyn, D. (2008) Inhibitory effect of curcuminoids and tetrahydrocurcuminoids on equine activated neutrophils and myeloperoxidase activity. Physiol. Res. 57, 577-587.
Freeman, S.L., Bowen, I.M., Bettschart-Wolfensberger, R., Alibhai, H.I.K. and England, C.G.W. (2002) Cardiovascular effects of romifidine in the standing horse. Res. Vet. Sci. 72, 123-129.
Furr, M. (2008) Monitoring and treating the neurological system. In: The Equine Hospital Manual, Eds: K.T.T. Corley and J. Stephen, Blackwell Publishing, Oxford. pp 457-483.
Giguere, S. (2008) Antimicrobial therapy. In: The Equine Hospital Manual, Eds: K.T.T. Corley and J. Stephen, Blackwell Publishing, Oxford. pp 337-361.
Heyman, S.N., Rosen, S. and Epstein, F.H. (1994) Loop diuretics reduce hypoxic damage to proximal tubules of the isolated perfused rat kidney. Kidney Int. 45, 981-985.
Hollis, A. and Corley, K.T.T. (2008) Monitoring and treating the urogenital system. In: The Equine Hospital Manual, Eds: K.T.T. Corley and J. Stephen, Blackwell Publishing, Oxford. pp 533-556.
Lee, Y.H., Clarke, K.W. and Alibhai, H.I.K. (1998) Effects of dopamine, dobutamine, dopexamine, phenylephrine, and saline solution on intramuscular blood flow and other cardiopulmonary variables in halothane-anesthetized ponies. Am. J. Vet. Res. 59, 1463-1472.
MacKay, R.J. (2007) Tetanus. In: Equine Infectious Diseases, Eds: D.C. Sellon and M.T. Long, Saunders Elsevier, St Louis. p 653.
Maranon, G., Munoz-Escassi, B., Manley, W., Garcia, C., Cayado, P., Sanchez de la Muela, M., Olabarri, B. and Vara, E. (2008) The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise. Acta Vet. Scand. 50, 45.
Marshall, J.C. and Blikslager, A.T. (2011) The effect of nonsteroidal anti-inflammatory drugs on the equine intestine. Equine Vet. J., Suppl. 39, 140-144.
McEwen, S.A. and Hulland, T.J. (1986) Histochemical and morphometric evaluation of skeletal muscle from horses with exertional rhabdomyolysis (tying-up). Vet. Pathol. 23, 400-410.
McKenzie, H.C. (2008) Monitoring and treating the respiratory system. In: The Equine Hospital Manual, Eds: K.T.T. Corley and J. Stephen, Blackwell Publishing, Oxford. pp 457-483.
Mehta, R., Chan, K., Lee, O., Tafazoli, S. and O'Brien, P.J. (2008) Drug-associated mitochondrial toxicity. In: Drug-Induced Mitochondrial Dysfunction, Eds: J.A. Dykens and Y. Will, Wiley, Hoboken. pp 71-127.
Menzies-Gow, N. (2008) Management of rhabdomyolysis and myopathy. In: The Equine Hospital Manual, Eds: K.T.T. Corley and J. Stephen, Blackwell Publishing, Oxford. pp 587-591.
Nout, Y.S. and Reed, S.M. (2005) Management and treatment of the recumbent horse. Equine Vet. Educ. 17, 324-336.
Puyalto-Moussu, C., Saison, A. and Leconte, D. (2004) Myoglobinurie atypique: epidemiologie de cas Francais de myopathie aigue. Prat. Vet. Equine 36, 29-35.
Robinson, N.E. (2003) Current Therapy in Equine Medicine, 5th edn., W.B. Saunders, Philadelphia.
Sharkey, B. and Herbots, P. (2008) Physiotherapy: indications and treatments techniques. In: The Equine Hospital Manual, Eds: K.T.T. Corley and J. Stephen, Blackwell Publishing, Oxford. pp 638-653.
Tinworth, K.D., Harris, P., Sillence, M.N. and Noble, G.K. (2010) Potential treatments for insulin resistance in the horse: a comparative multi-species review. Vet. J. 186, 282-291.
Unger-Torroledo, L., Straub, R., Lehmann, A.D., Graber, F., Stahl, C., Frey, J., Gerber, V., Hoppeler, H. and Baum, O. (2010) Lethal toxin of Clostridium sordellii is associated with fatal equine atypical myopathy. Vet. Microbiol. 20, 487-492.
Van Galen, G. (2008) Epidemiological and pathophysiological study of atypical myopathy in grazing horses. Master of Science project, Faculty of Veterinary Medicine, University of Liège.
Van Galen, G., Amory, H., Busschers, E., Cassart, D., de Bruijn, M., Gerber, V., Keen, J., Lefere, L., Marcillaud Pitel, C., Marr, C., Muller, J.M.V., Pineau, X., Saegerman, C., Sandersen, C., Serteyn, D., Torfs, S., Unger, L., Verwilghen, D. and Votion, D. (2010) European outbreak of atypical myopathy in the fall 2009. J. Vet. Emerg. Crit. Care 20, 528-532.
Van Galen, G., Cerri, S., Porter, S., Saegerman, C., Lefere, L., Roscher, K., Marr, C., Amory, H. and Votion, D.M. (2011) Assessment of acid-base imbalances in horses suffering from atypical myopathy. Proc. Am. Ass. Equine Practnrs. 57, 248-249.
Van Galen, G., Marcillaud Pitel, C., Saegerman, C., Patarin, F., Amory, H., Baily, J.D., Cassart, D., Gerber, V., Hahn, C.N., Harris, P., Keen, J.A., Kirschvink, N., Lefere, L., McGorum, B., Muller, J.M.V., Picavet, M.T.J.E., Piercy, R., Roscher, K., Serteyn, D., Unger, L., van der Kolk, J.H., van Loon, G., Verwilghen, D., Westermann, C.M. and Votion, D.M. (2012a) European outbreaks of atypical myopathy in grazing equids (2006-2009). Spatiotemporal distribution, history and clinical features. Equine Vet. J. 44, 614-620.
Van Galen, G., Marcillaud Pitel, C., Saegerman, C., Patarin, F., Amory, H., Baily, J.D., Cassart, D., Gerber, V., Hahn, C.N., Harris, P., Keen, J.A., Kirschvink, N., Lefere, L., McGorum, B., Muller, J.M.V., Picavet, M.T.J.E., Piercy, R., Roscher, K., Serteyn, D., Unger, L., van der Kolk, J.H., van Loon, G., Verwilghen, D., Westermann, C.M. and Votion, D.M. (2012b) European outbreaks of atypical myopathy in grazing horses (2006-2009). Determination of indicators for risk and prognostic factors. Equine Vet. J. 44, 621-625.
Votion, D.M., Amory, H., Demoulin, V., Desmecht, D., Rollin, F., Thiry, E., Baise, E., Cassart, D., Delguste, C., Piat, E., Sandersen, C. and Linden, A. (2004) Atypical myopathy (atypical myoglobinuria). In: IVIS Reviews in Veterinary Medicine, International Veterinary Information Service, Ithaca, NY, USA.
Votion, D.M., Linden, A., Saegerman, C., Engels, P., Erpicum, M., Thiry, E., Delguste, C., Rouxhet, S., Demoulin, V., Navet, R., Sluse, F., Serteyn, D., van Galen, G. and Amory, H. (2007) History and clinical features of atypical myopathy in horses in Belgium (2000-2005). J. Vet. Intern. Med. 21, 1380-1391.
Westermann, C.M. (2011) The effect of longterm oral L-carnitine administration on insulin sensitivity, glucose disposal, plasma concentrates of leptin and acylcarnitines and urinary acylcarnitine excretion in warmblood horses. In: Proceedings of the ECEIM Congress 2011.
Westermann, C.M., Dorland, L., Votion, D.M., De Sain-van der Velden, M.G.M., Wijnberg, I.D., Wanders, R.J.A., Spliet, W.G.M., Testerink, N., Berger, R., Ruiter, J.P.N. and van der Kolk, H.J. (2008) Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy. Neuromuscul. Disord. 18, 355-364.
Whitwell, K.E., Harris, P. and Farrington, P.G. (1988) Atypical myoglobinuria - an acute myopathy in grazing horses. Equine Vet. J. 20, 357-363.
Wilkins, P.A. and Palmer, J.E. (2003) Mechanical ventilation in foals with botulism: 9 cases (1989-2002). J. Vet. Intern. Med. 17, 708-712.
Wilson, D.V., Schott, H.C., Robinson, N.E., Berney, C.E. and Eberhart, S.W. (2006) Response to nasopharyngeal oxygen administration in horses with lung disease. Equine Vet. J. 38, 219-223.
