Management of cases suffering from atypical myopathy:Interpretations of descriptive, epidemiological and pathophysiological findings. Part 1: First aid, cardiovascular, nutritional and digestive care
Van Galen, Gaby; Votion, Dominique
2013 • In Equine Veterinary Education, 25 (5), p. 264-270
[en] Atypical myopathy is highly fatal, but about a quarter of
affected horses survive. This highlights the need for
provision of supportive treatment for these cases. This
review is a practical guideline for equine practitioners and
includes suggestions for close monitoring of involved organ
systems and discusses options of supportive treatment
based on current knowledge of the condition.
Research Center/Unit :
FVM, ULG
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Van Galen, Gaby ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Epidémiologie et analyse des risques appl. aux sc. vétér.
Votion, Dominique ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Language :
English
Title :
Management of cases suffering from atypical myopathy:Interpretations of descriptive, epidemiological and pathophysiological findings. Part 1: First aid, cardiovascular, nutritional and digestive care
Publication date :
2013
Journal title :
Equine Veterinary Education
ISSN :
0957-7734
eISSN :
2042-3292
Publisher :
Equine Veterinary Journal, Newmarket, United Kingdom
Baggot, J.D. (1995) The pharmacological basis of cardiac drug selection for use in horses. Equine Vet. J., Suppl. 19, 97-100.
Barker, W.H.J., Roberts, V., Williams, A. and McKane, S.A. (2008) High dose insulin therapy for the treatment of hyperlipaemia and associated insulin resistance. In: Proceedings of the 47th British Equine Veterinary Association Congress, Equine Veterinary Journal Ltd, Fordham. pp 135-136.
Brandt, K., Hinrichs, U., Glitz, F., Landes, E., Schulze, C., Deegen, E., Pohlenz, J. and Coenen, M. (1997) Atypical myoglobinuria in grazing horses. Pferdeheilkunde 13, 27-34.
Cassart, D., Baise, E., Cherel, Y., Delguste, C., Antoine, N., Votion, D., Amory, H., Rollin, F., Linden, A., Coignoul, F. and Desmecht, D. (2007) Morphological alterations in oxidative muscles and mitochondrial structure associated with equine atypical myopathy. Equine Vet. J. 39, 26-32.
Corley, K.T.T. (2004) Fluid therapy. In: Equine Clinical Pharmacology, Eds: J. Bertone and L.J.I. Horspool, W.B. Saunders, Toronto. pp 327-364.
Corley, K.T.T. (2008) Fluid therapy. In: The Equine Hospital Manual, Eds: K.T.T. Corley and J. Stephen, Blackwell Publishing, Oxford. pp 364-392.
Corley, K.T.T. and Marr, C.M. (1998) Pathophysiology, assessment and treatment of acid-base disturbances in the horse. Equine Vet. Educ. 10, 255-265.
Corley, K.T.T. and Stephen, J. (2008) The Equine Hospital Manual, Blackwell Publishing, Oxford.
Delesalle, C., Dewulf, J., Lefebvre, R.A., Schuurkes, J.A.J., Van Vlierbergen, B. and Deprez, P. (2005) Use of plasma ionized Ca2+ levels and Ca2+ substitution response patterns as prognostic parameters for ileus and survival in colic horses. Vet. Q. 27, 158-172.
Delguste, C., Cassart, D., Baise, E., Linden, A., Schwarzwald, C., Feige, K., Sandersen, C., Rollin, F. and Amory, H. (2002) Atypical myoglobinuria in grazing horses: an outbreak in Belgium. Ann. Med. Vet. 146, 235-247.
Dunkel, B. (2008) Hyperlipaemia. In: The Equine Hospital Manual, Eds: K.T.T. Corley and J. Stephen, Blackwell Publishing, Oxford. pp 399-340.
Dunkel, B. and McKenzie, H.C. (2003) Severe hypertriglyceridaemia in clinically ill horses: diagnosis, treatment and outcome. Equine Vet. J. 35, 590-595.
Durando, M. (2008) Treating problems of the heart. In: The Equine Hospital Manual, Eds: K.T.T. Corley and J. Stephen, Blackwell Publishing, Oxford. pp 436-446.
Durham, A.E., Phillips, T.J., Walmsley, J.P. and Newton, J.R. (2003) Study of the clinical effects of postoperative parenteral nutrition in 15 horses. Vet. Rec. 153, 493-498.
Durham, A.E., Phillips, T.J., Walmsley, J.P. and Newton, J.R. (2004) Nutritional and clinicopathological effects of postoperative parenteral nutrition following small intestinal resection and anastomosis in the mature horse. Equine Vet. J. 36, 390-396.
Finno, C.J., Valberg, S.J., Wunschmann, A. and Murphy, M.J. (2006) Seasonal pasture myopathy in horses in the midwestern United States: 14 cases (1998-2005). J. Am. Vet. Med. Assoc. 229, 1134-1141.
Firshman, A.M. and Valberg, S.J. (2007) Factors affecting clinical assessment of insulin sensitivity in horses. Equine Vet. J. 39, 567-575.
Furr, M., Cohen, N.D., Axon, J.E., Sanchez, L.C., Pantaleon, L., Haggett, E., Campbell, R. and Tennet-Brown, B. (2012) Treatment with histamine-type 2 receptor antagonists and omeprazole increase the risk of diarrhoea in neonatal foals treated in intensive care units. Equine Vet. J. Suppl. 41, 80-86.
Galvin, N., Dillon, H. and McGovern, F. (2004) Right dorsal colitis in the horse: minireview and reports on three cases in Ireland. Ir. Vet. J. 57, 467-473.
Glazier, D.B., Littledike, E.T. and Evans, R.D. (1979) Electrocardiographic changes in induced hypocalcemia and hypercalcemia in horses. J. Equine Med. Surg. 3, 489-494.
Han, J.H., McKenzie, H.C., McCutcheon, L.J. and Geor, R.J. (2011) Glucose and insulin dynamics associated with continuous rate infusion of dextrose solution or dextrose solution and insulin in healthy and endotoxin-exposed horses. Am. J. Vet. Res. 72, 522-529.
Hassel, D.M., Smith, P.A., Nieto, J.E., Beldomenico, P. and Spier, S.J. (2009) Di-tri-octahedral smectite for the prevention of post-operative diarrhea in equids with surgical disease of the large intestine: results of a randomized clinical trial. Vet. J. 182, 210-214.
Hosie, B.D., Gould, P.W., Hunter, A.R., Low, J.C., Munro, R. and Wilson, H.C. (1986) Acute myopathy in horses at grass in east and south east Scotland. Vet. Rec. 119, 444-449.
Johnson, P.J. (1995) Electrolyte and acid-base disturbances in the horse. Vet. Clin. North Am. Equine Pract. 11, 491-514.
Krinsley, J.S., Meyfroidt, G., Van den Berghe, G., Eqi, M. and Bellomo, R. (2012) The impact of premorbid diabetic status on the relationship between the three domains of glycemic control and mortality in critically ill patients. Curr. Opin. Clin. Nutr. Metab. Care 15, 151-160.
Lester, G.D., Smith, R.L. and Robertson, I.D. (2005) Effects of treatment with omeprazole or ranitidine on gastric squamous ulceration in racing Thoroughbreds. J. Am. Vet. Med. Assoc. 22715, 1636-1639.
Lopes, M.A. and White, N.A.N. (2002) Parenteral nutrition for horses with gastrointestinal disease: a retrospective study of 79 cases. Equine Vet. J. 34, 250-257.
MacLeah, J.M., Valberg, S., Pagan, J.D., de laCorte, F., Roberts, F., Billstrom, J., McGinnity, J. and Kaese, H. (1999) Effect of diet on thoroughbred horses with recurrent exertional rhabdomyolysis performing a standardised exercise test. Equine Vet. J. Suppl. 30, 458-462.
MacLeay, J.M. (2004) Diseases of the muskuloskeletal system. In: Equine Internal Medicine, Eds: D.C. Sellon, S.M. Reed and W.M. Bayly, W.B. Saunders, Philadelphia. pp 461-522.
Malcolm, D.S., Zaloga, G.P. and Holaday, J.W. (1989) Calcium administration increases the mortality of endotoxic shock in rats. Crit. Care Med. 17, 900-903.
McKenzie, E.C. and Firshman, A.M. (2009) Optimal diet of horses with chronic exertional myopathies. Vet. Clin. N. Am.: Equine Pract. 25, 121-135.
Moursi, M., Rising, C.L., Zelenock, G.B. and D'Alecy, L.G. (1987) Dextrose administration exacerbates acute renal ischemic damage in anesthetized dogs. Arch. Surg. 122, 790-794.
Muir, W.W. and McGuirk, S.M. (1985) Pharmacology and pharmacokinetics of drugs used to treat cardiac diseases in horses. Vet. Clin. N. Am.: Equine Pract. 1, 335-352.
Nout, Y.S. and Reed, S.M. (2005) Management and treatment of the recumbent horse. Equine Vet. Educ. 17, 324-336.
Palencia, P. and Rivero, J.L.L. (2007) Atypical myopathy in two grazing horses in northern Spain. Vet. Rec. 161, 346-348.
Puyalto-Moussu, C., Saison, A. and Leconte, D. (2004) Myoglobinurie atypique: epidemiologie de cas Francais de myopathie aigue. Prat. Vet. Equine 36, 29-35.
Serteyn, D., Mottart, E., Deby, C., Deby-Dupont, G., Pincemail, J., Philipart, C. and Lamy, M. (1990) Equine postanaesthetic myositis - a possible role for free-radical generation and membrane lipoperoxidation. Res. Vet. Sci. 48, 42-46.
Sherlock, C.E. and Mair, T.S. (2008) Concurrent atypical myoglobinuria and colon displacement in a filly. Equine Vet. Educ. 20, 228-233.
Stratton-Phelps, M. (2008) Nutritional management of the hospitalised horse. In: The Equine Hospital Manual, Eds: K.T.T. Corley and J. Stephen, Blackwell Publishing, Oxford. pp 261-311.
Sweeney, R.W. and Hansen, T.O. (1990) Use of a liquid diet as the sole source of nutrition in six dysphagic horses and as a dietary supplement in seven hypophagic horses. J. Am. Vet. Med. Assoc. 197, 1030-1032.
Tiley, H.A., Geor, R.J. and McCutcheon, L.J. (2008) Effects of dexamethasone administration on insulin resistance and components of insulin signaling and glucose metabolism in equine skeletal muscle. Am. J. Vet. Res. 69, 51-58.
Unger-Torroledo, L., Straub, R., Lehmann, A.D., Graber, F., Stahl, C., Frey, J., Gerber, V., Hoppeler, H. and Baum, O. (2010) Lethal toxin of Clostridium sordellii is associated with fatal equine atypical myopathy. Vet. Microbiol. 20, 487-492.
Van Galen, G., Cerri, S., Porter, S., Saegerman, C., Lefere, L., Roscher, K., Marr, C., Amory, H. and Votion, D.M. (2011) Assessment of acid-base imbalances in horses suffering from atypical myopathy. Proc. Am. Ass. Equine Practnrs. 57, 248-249.
Van Galen, G., Marcillaud Pitel, C., Saegerman, C., Patarin, F., Amory, H., Baily, J.D., Cassart, D., Gerber, V., Hahn, C.N., Harris, P., Keen, J.A., Kirschvink, N., Lefere, L., McGorum, B., Muller, J.M.V., Picavet, M.T.J.E., Piercy, R., Roscher, K., Serteyn, D., Unger, L., van der Kolk, J.H., van Loon, G., Verwilghen, D., Westermann, C.M. and Votion, D.M. (2012a) European outbreaks of atypical myopathy in grazing equids (2006-2009). Spatiotemporal distribution, history and clinical features. Equine Vet. J. 44, 614-620.
Van Galen, G., Marcillaud Pitel, C., Saegerman, C., Patarin, F., Amory, H., Baily, J.D., Cassart, D., Gerber, V., Hahn, C.N., Harris, P., Keen, J.A., Kirschvink, N., Lefere, L., McGorum, B., Muller, J.M.V., Picavet, M.T.J.E., Piercy, R., Roscher, K., Serteyn, D., Unger, L., van der Kolk, J.H., van Loon, G., Verwilghen, D., Westermann, C.M. and Votion, D.M. (2012b) European outbreaks of atypical myopathy in grazing horses (2006-2009). Determination of indicators for risk and prognostic factors. Equine Vet. J. 44, 621-625.
Van Herpe, T., Vanhonsebrouck, K., Mesotten, D., De Moor, B. and Van den Berghe, G. (2012) Glycemic control in the pediatric intensive care unit of Leuven: two years of experience. J. Diabetes Sci. Technol. 6, 15-21.
Verheyen, T., Decloedt, A., De Clercq, D. and van Loon, G. (2012) Cardiac changes in horses with atypical myopathy. J. Vet. Intern. Med. 26, 1019-1026.
Votion, D.M., Amory, H., Demoulin, V., Desmecht, D., Rollin, F., Thiry, E., Baise, E., Cassart, D., Delguste, C., Piat, E., Sandersen, C. and Linden, A. (2004) Atypical myopathy (atypical myoglobinuria). In: IVIS Reviews in Veterinary Medicine, International Veterinary Information Service, Ithaca.
Votion, D.M., Linden, A., Delguste, C., Amory, H., Thiry, E., Engels, P., van Galen, G., Navet, R., Sluse, F., Serteyn, D. and Saegerman, C. (2009) Atypical myopathy in grazing horses: a first exploratory data analysis. Vet. J. 180, 77-87.
Votion, D.M., Linden, A., Saegerman, C., Engels, P., Erpicum, M., Thiry, E., Delguste, C., Rouxhet, S., Demoulin, V., Navet, R., Sluse, F., Serteyn, D., van Galen, G. and Amory, H. (2007) History and clinical features of atypical myopathy in horses in Belgium (2000-2005). J. Vet. Intern. Med. 21, 1380-1391.
Waitt, L.H. and Cebra, C.K. (2009) Characterization of hypertriglyceridemia and response to treatment with insulin in horses, ponies, and donkeys: 44 cases (1995-2005). J. Am. Vet. Med. Assoc. 234, 915-919.
Watson, T.D., Murphy, D. and Love, S. (1992) Equine hyperlipaemia in the United Kingdom: clinical features and blood biochemistry of 18 cases. Vet. Rec. 131, 48-51.
Westermann, C.M., de Sain-van der Velden, M.G.M., van der Kolk, J.H., Berger, R., Wijnberg, I.D., Koeman, J.P., Wanders, R.J.A., Lenstra, J.A., Testerink, N., Vaandrager, A.B., Vianey-Saban, C., Acquaviva-Bourdain, C. and Dorland, L. (2007) Equine biochemical multiple acyl-CoA dehydrogenase deficiency (MADD) as a cause of rhabdomyolysis. Mol. Genet. Metab. 91, 362-369.
Westermann, C.M., Dorland, L., Van Diggelen, O.P., Schoonderwoerd, K., Bierau, J., Waterham, H.R. and Van der Kolk, H. (2011) Decreased oxidative phosphorylation and PGAM deficiency in horses suffering from atypical myopathy associated with acquired MADD. Mol. Genet. Metab. 104, 273-278.
Westermann, C.M., Dorland, L., Votion, D.M., De Sain-van der Velden, M.G.M., Wijnberg, I.D., Wanders, R.J.A., Spliet, W.G.M., Testerink, N., Berger, R., Ruiter, J.P.N. and van der Kolk, H.J. (2008) Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy. Neuromuscul. Disord. 18, 355-364.
White, G., McClure, S.R., Sifferman, R., Holste, J.E., Fleishman, C., Murray, M.J. and Cramer, L.G. (2007) Effects of short-term light to heavy exercise on gastric ulcer development in horses and efficacy of omeprazole paste in preventing gastric ulceration. J. Am. Vet. Med. Assoc. 230, 1680-1682.
Whitwell, K.E., Harris, P. and Farrington, P.G. (1988) Atypical myoglobinuria - an acute myopathy in grazing horses. Equine Vet. J. 20, 357-363.
Wrogemann, K. and Pena, S.D. (1976) Mitochondrial calcium overload: a general mechanism for cell-necrosis in muscle diseases. Lancet 1, 672-674.
Zaloga, G.P., Sager, A., Black, K.W. and Prielipp, R. (1992) Low dose calcium administration increases mortality during septic peritonitis in rats. Circ. Shock 37, 226-229.
