Ustekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis. A primer.

[en] Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with systemic comorbidities. The pathogenic importance of interleukin (IL)-12 and IL-23 is beyond doubt, as well as the involvement of T helper cells (Th)1 and Th17 cells. There is upregulation of the p40 subunit shared by IL-12 and IL-23 and of the IL-23 p19 subunit, but not an increased expression of the IL-12 p35 subunit. This indicates that IL-23 appears more involved than IL-12 in the pathogenesis of psoriatic plaques. Ustekinumab is a fully human monoclonal antibody of the immunoglobulin (Ig) G1 class targeting the p40 subunit common to both IL-12 and IL-23, thus inhibiting both IL-12 and IL-23 receptor-mediated signalling. Ustekinumab is part of the recent biologic therapies active in psoriasis, autoimmune arthritides, and inflammatory bowel diseases.

Disciplines :

Dermatology

Author, co-author :

QUATRESOOZ, Pascale ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Hermanns-Lê, Trinh ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Pierard, Gérald ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Humbert, Philippe

DELVENNE, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique

FRANCHIMONT, Claudine ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Language :

English

Title :

Ustekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis. A primer.

Publication date :

2012

Journal title :

Journal of Biomedicine and Biotechnology

ISSN :

1110-7243

eISSN :

1110-7251

Publisher :

Hindawi Publishing Corporation, United States

Volume :

2012

Issue :

147413

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 July 2012

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Bibliography

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