[en] BACKGROUND: More than 90% of vitamin D synthesis is dependent on UV exposure. Photosensitive disorders such as lupus erythematosus, protoporphyria and xeroderma require strict sun avoidance, and vitamin D deficiency has been demonstrated in these patients. Melanoma patients are also instructed to avoid sun exposure and may hence be expected to be vitamin D deficient.
MATERIALS AND METHODS: Winter and summer vitamin D levels were compared in a group of melanoma patients (n =61) and age- and phototype-matched controls (n = 53) without photosensitive disorders.
RESULTS: Oral supplementary vitamin D intake was reported in 32.7% of the melanoma patients and in 15.1% in the control group. Despite oral supplementation, only 25% of the melanoma patients and the controls presented with vitamin D levels of 30 ng/mL or higher. In non-supplemented subjects in the melanoma and control groups, respectively, mean winter vitamin D levels were below the recommended threshold at 12.6 ng/mL vs. 13.2 ng/mL, respectively, but not statistically different. These values increased significantly in both groups during the summer to 24.6 and 23.8 ng/mL respectively.
CONCLUSION: Unexpected, significant increases in vitamin D levels were seen in melanoma patients during summer, suggesting non-adherence with photoprotective measures and reflecting a heliophilic behaviour. Vitamin D supplementation is recommended in melanoma patients during both winter and summer.
Disciplines :
Laboratory medicine & medical technology Dermatology
Author, co-author :
FAILLA, Valérie ; Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
CAVALIER, Etienne ; Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
EL HAYDERI, Lara ; Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
PAUROBALLY, Dilshad ; Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
Chapelle, Jean-Paul ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale
DEZFOULIAN, Bita ; Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
NIKKELS, Arjen ; Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
Language :
English
Title :
Seasonal variations in vitamin D levels in melanoma patients: a single-centre prospective pilot comparative study
Publication date :
2012
Journal title :
Journal of the European Academy of Dermatology and Venereology
Holick MF,. Vitamin D deficiency. N Eng J Med 2007; 357: 266-281.
Souberbielle JC, Body JJ, Lappe JM, et al. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: recommendations for clinical practice. Autoimmun Rev 2010; 9: 709-715.
Reginster JY,. The high prevalence of inadequate serum vitamin D levels and implications for bone health. Curr Med Res Opin 2005; 21: 579-586.
Judd SE, Tangpricha V,. Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci 2009; 338: 40-44.
Grant WB, Mohr SB,. Ecological studies of ultraviolet B, vitamin D and cancer since 2000. Ann Epidemiol 2009; 19: 446-454.
Pierrot-Deseilligny C,. Clinical implications of a possible role of vitamin D in multiple sclerosis. J Neurol 2009; 256: 1468-1479.
Cannell JJ, Vieth R, Umhau JC, et al. Epidemic influenza and vitamin D. Epidemiol Infect 2006; 134: 1129-1140. (Pubitemid 44614932)
Cherniack EP, Troen BR, Florez HJ, et al. Some new food for thought: the role of vitamin D in the mental health of older adults. Curr Psychiatry Rep 2009; 11: 12-19.
Stroud ML, Stilgoe S, Stott VE, et al. Vitamin D-a review. Aust Fam Physician 2008; 37: 1002-1005.
Reichrath J,. Sunlight, skin cancer and vitamin D: what are the conclusions of recent findings that protection against solar ultraviolet (UV) radiation causes 25-hydroxyvitamin D deficiency in solid organ-transplant recipients, xeroderma pigmentosum, and other risk groups? J Steroid Biochem Mol Biol 2007; 103: 664-667. (Pubitemid 46420522)
Rigel DS,. Cutaneous ultraviolet exposure and its relationship to the development of skin cancer. J Am Acad Dermatol 2008; 58: S129-S132. (Pubitemid 351506511)
Chang YM, Barrett JH, Bishop DT, et al. Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls. Int J Epidemiol 2009; 38: 814-830.
Querings K, Reichrath J,. A plea for the analysis of Vitamin-D levels in patients under photoprotection, including patients with xeroderma pigmentosum (XP) and basal cell nevus syndrome (BCNS). Cancer Causes Control 2004; 15: 219. (Pubitemid 38445369)
Ruiz-Irastorza G, Egurbide MV, Olivares N, et al. Vitamin D deficiency in systemic lupus erythematosus: prevalence, predictors and clinical consequences. Rheumatology 2008; 47: 920-923. (Pubitemid 351796385)
Holme SA, Anstey AV, Badminton MN, Elder GH,. Serum 25-hydroxyvitamin D in erythropoietic protoporphyria. Br J Dermatol 2008; 159: 211-213. (Pubitemid 351874500)
Matsuoka LY, Wortsman J, Hollis BW,. Use of topical sunscreen for the evaluation of regional synthesis of vitamin D3. J Am Acad Dermatol 1990; 22: 772-775. (Pubitemid 20154075)
Freiman A, Yu J, Loutfi A, Wang B,. Impact of melanoma diagnosis on sun-awareness and protection: efficacy of education campaigns in a high-risk population. J Cutan Med Surg 2004; 8: 303-309. (Pubitemid 41542420)
Rossi JS, Blais LM, Redding CA, et al. Preventing skin cancer through behavior change. Implications for interventions. Dermatol Clin 1995; 13: 613-622.
Ismail F, Mitchell L, Casabonne D, et al. Specialist dermatology clinics for organ transplant recipients significantly improve compliance with photoprotection and levels of skin cancer awareness. Br J Dermatol 2006; 155: 916-925. (Pubitemid 44564499)
Azurdia RM, Pagliaro JA, Diffey BL, Rhodes LE,. Sunscreen application by photosensitive patients is inadequate for protection. Br J Dermatol 1999; 140: 255-258. (Pubitemid 29111352)
Berwick M, Armstrong BK, Ben-Porat L, et al. Sun exposure and mortality from melanoma. J Natl Cancer Inst 2005; 97: 195-199. (Pubitemid 40277369)
