Galectin-1 in Melanoma Biology and Related Neo-Angiogenesis Processes.

[en] Aggressiveness of advanced melanomas relates in part to their marked propensity to develop neoangiogenesis and metastases. Among its numerous pro-cancer roles, galectin (gal)-1 expressed and/or secreted by both cancer and endothelial cells stimulates proliferation and angiogenesis. This study first shows that gal-1 is more highly expressed at both mRNA and protein levels than its congeners in melanomas and particularly in advanced lesions. The roles of gal-1 were further investigated in vivo in the highly proliferating and vascularized pseudometastatic B16F10 mouse melanoma model using stable knockdown B16F10 cells and wild-type versus gal-1 knockout mice, and then in vitro in B16F10 tumoral and lung microvascular cells. Gal-1 depletion in the B16F10 tumor cells but not in the tumor-bearing mice significantly increased melanoma-bearing mice survival. Tumor-derived gal-1 thus seems to have more critical roles than the host-derived one. In fact, gal-1 displays distinct effects on the H-Ras-dependent p53/p21 pathways: in primary lung microvessel endothelial cells, gal-1 seems to be involved in the maintenance of senescent status through the induction of both p53 and p21 while it stimulates B16F10 cancer cell proliferation through a p53/p21 decrease. Altogether, these data point to gal-1 as a potential target to combat melanomas.Journal of Investigative Dermatology advance online publication, 24 May 2012; doi:10.1038/jid.2012.142.

Research Center/Unit :

Giga-Cancer - ULiège

Disciplines :

Biochemistry, biophysics & molecular biology
Oncology

Author, co-author :

Mathieu, V.

de Lassalle, Elisabeth Martin

Toelen, J.

Mohr, T.

Bellahcene, Akeila ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases

Van, Goietsenoven

Verschuere, T.

Bouzin, C.

Debyser, Z.

De Vleesschouwer, Steven

More authors (5 more)

Language :

English

Title :

Galectin-1 in Melanoma Biology and Related Neo-Angiogenesis Processes.

Publication date :

2012

Journal title :

Journal of Investigative Dermatology

ISSN :

0022-202X

eISSN :

1523-1747

Publisher :

Nature Publishing Group, New York, United States - New York

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

Fonds Yvonne Boël
F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 27 June 2012

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