[en] A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most mammals ultizes an immunoassay to detect fragments of collagen type II resulting from collagenase activity comprising an antibody directed against an epitope comprised in the amino acid sequence HRGYPGLDG, located in the helical region of collagen type II.
Disciplines :
Rheumatology
Inventor :
Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Deberg, Michelle
Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)
Christgau, Stephan
Language :
English
Title (54) :
METHOD FOR MONITORING COLLAGEN TYPE II DEGRADATION IN CARTILAGE
Publication date (43-45) :
15 December 2004
Filing date (22) :
12 March 2003
Patent/publication number (10-11) :
EP1485718 A2
Patent status (13) :
A
Priority number (30) :
20020363926P US 13.03.2002
International classification (IPC) (51) :
C07K16/18; G01N33/68; (IPC1-7): G01N33/68
European classification (ECLA) (52) :
C07K16/18; G01N33/68R
Applicant (71) :
Université de Liège Avenue Pré-Aily, 4 4031 Angleur / BE
