Reference : Chapter 17: Thiamin (E-book)
Parts of books : Contribution to collective works
Life sciences : Biochemistry, biophysics & molecular biology
Chapter 17: Thiamin (E-book)
Bettendorff, Lucien mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
10th Edition
Present Knowledge in Nutrition (E-book)
Erdman, Jr, John W.
MacDonald, Ian A. mailto
Zeisel, Steven H. mailto
[en] thiamine
[en] Thiamin (vitamin B1) was the first vitamin characterized and its discovery was at the origin of the concept of vitamin. Thiamin deficiency mainly affects the nervous system and causes two classical diseases, beriberi (a polyneuritic syndrome) and Wernicke-Korsakoff syndrome (anterograde amnesia resulting from brain lesions in alcoholics). Thiamin transport through the membranes of intestinal and other cells requires specific carriers. As the process is rather slow, various lipid-soluble thiamin precursors with better bioavailability have been developed. In the cytosol, thiamin is pyrophosphorylated to thiamin diphosphate (ThDP), an indispenable cofactor in cell energy metabolism. Therefore, thiamin deficiency causes decreased cofactor function, leading to neuronal death. In addition, non-cofactor roles of the triphosphorylated derivatives thiamin triphosphate (ThTP) and adenosine thiamin triphosphate (AThTP) may play a role in metabolic regulation and may contribute to the pathology of thiamin deficiency-induced brain lesions. Current research interests are focused on the metabolism and role of thiamin derivatives (especially in catalysis by ThDP-dependent enzymes) and the biochemical and pathophysiological mechanisms by which thiamin deficiency induces specific brain lesions and may be implicated in other disorders such as Alzheimer’s disease and diabetes.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students ; General public

File(s) associated to this reference

Fulltext file(s):

Restricted access
Thiamine nutrition.pdfPublisher postprint1.07 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.