[en] In 11 patients with megaloblastic anemia, transfusion of packed erythrocytes or washed erythrocytes invariably resulted in a decline in plasma iron concentration to a range of 20-90 µg/dl (3.6 - 16 µmol/l) after 36 or 48 hours. The same phenomenon was observed in two of six cases of ineffective erythropoiesis without megaloblastosis and in none of five cases of aplastic anemia. The observed changes did not result from a specific hematinic response or from iron uptake by a non-erythroid compartment. In megaloblastic anemia, alteration in marrow function in response to transfusion was reflected by plasma iron kinetics and serum lactate dehydrogenase values, which indicated marked reductions in both marrow hyperplasia and ineffective erythropoieseis. Transfusion in megaloblastic anemia was also responsible for a 50% reduction in platelet count after 2 to 6 days. The significance of these changes is discussed.
Disciplines :
Hematology
Author, co-author :
Fillet, Georges ; Université de Liège - ULiège > Département des sciences cliniques > Hématologie - Oncologie médicale
Andrien, J.-M.
Bury, Jean
Language :
French
Title :
Effects of transfusion on serum iron, serum lactate dehydrogenase and platelets in megaloblastic anemia
Publication date :
1977
Journal title :
American Journal of Clinical Pathology
ISSN :
0002-9173
Publisher :
American Society of Clinical Pathologists, Chicago, United States - Illinois