L'estimation du débit de filtration glomérulaire en 2012: quelle valeur ajoutée pour la nouvelle équation CKD-EPI

[fr] Mesurer ou estimer le debit de filtration glomerulaire (DFG) reste l’un des meilleurs moyens d’apprehender la fonction glomerulaire du rein. En 2009, l’equation Chronic Kidney Disease Epidemiology (CKD-EPI) a ete proposee en lieu et place de l’equation Modification of Diet in Renal Disease (MDRD) pour estimer le DFG. Cette nouvelle equation fait partie desormais des toutes dernieres recommandations de la Haute Autorite de sante (HAS). Par rapport a MDRD, la formule CKD-EPI est sensee moins sous-estimer le DFG mesure, principalement dans les valeurs les plus hautes de DFG. Dans cette revue critique de la litterature, nous presenterons et discuterons les performances de cette nouvelle equation. Sur base des articles publies entre 2009 et 2012, nous en soulignerons les avantages, notamment en terme d’estimation de la prevalence de la maladie renale chronique (MRC), mais aussi les faiblesses, principalement dans certaines populations specifiques. En effet, toutes ces equations reposant sur la mesure de la creatinine serique restent des estimations et le nephrologue doit donc garder son sens critique dans l’interpretation de ces resultats.

Disciplines :

Urology & nephrology
Laboratory medicine & medical technology

Author, co-author :

DELANAYE, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Néphrologie

Mariat, Christophe

Moranne, Olivier

CAVALIER, Etienne ; Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale

Flamant, Martin

Language :

French

Title :

L'estimation du débit de filtration glomérulaire en 2012: quelle valeur ajoutée pour la nouvelle équation CKD-EPI

Alternative titles :

[en] Estimating glomerular filtration rate in 2012: which adding value for the CKD-EPI equation?

Publication date :

2012

Journal title :

Néphrologie et Thérapeutique

ISSN :

1769-7255

eISSN :

1872-9177

Publisher :

Elsevier, Paris, France

Volume :

Pages :

199-205

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 30 May 2012

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