CKD-EPI; Créatinine; Débit de filtration glomérulaire; MDRD
Abstract :
[fr] Mesurer ou estimer le debit de filtration glomerulaire (DFG) reste l’un des meilleurs moyens
d’apprehender la fonction glomerulaire du rein. En 2009, l’equation Chronic Kidney Disease
Epidemiology (CKD-EPI) a ete proposee en lieu et place de l’equation Modification of Diet in Renal Disease (MDRD) pour estimer le DFG. Cette nouvelle equation fait partie desormais des toutes dernieres recommandations de la Haute Autorite de sante (HAS). Par rapport a MDRD, la formule CKD-EPI est sensee moins sous-estimer le DFG mesure, principalement dans les valeurs les plus hautes de DFG. Dans cette revue critique de la litterature, nous presenterons et discuterons les performances de cette nouvelle equation. Sur base des articles publies entre 2009 et 2012, nous en soulignerons les avantages, notamment en terme d’estimation de la prevalence de la maladie renale chronique (MRC), mais aussi les faiblesses, principalement dans certaines populations specifiques. En effet, toutes ces equations reposant
sur la mesure de la creatinine serique restent des estimations et le nephrologue doit donc garder son sens critique dans l’interpretation de ces resultats.
Disciplines :
Urology & nephrology Laboratory medicine & medical technology
Author, co-author :
DELANAYE, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
Mariat, Christophe
Moranne, Olivier
CAVALIER, Etienne ; Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Flamant, Martin
Language :
French
Title :
L'estimation du débit de filtration glomérulaire en 2012: quelle valeur ajoutée pour la nouvelle équation CKD-EPI
Alternative titles :
[en] Estimating glomerular filtration rate in 2012: which adding value for the CKD-EPI equation?
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