Reference : Anti-UVC Irradiation and Metal Chelation Properties of 6-Benzoyl-5,7-dihydroxy-4-phen...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Life sciences : Biochemistry, biophysics & molecular biology
Physical, chemical, mathematical & earth Sciences : Chemistry
Anti-UVC Irradiation and Metal Chelation Properties of 6-Benzoyl-5,7-dihydroxy-4-phenyl-chromen-2-one: An Implication for Anti-Cataract Agent
Liao, Jiahn-Haur [Institute of Biological Chemistry > Academia Sinica, Taipei, Taiwan > > >]
Wu, Tzu-Hua [> >]
Hsu, Feng-Lin [> >]
Huang, Yi-Shiang mailto [Institute of Biological Chemistry > Academia Sinica, Taipei, Taiwan > > >]
Chiang, Po-Hung [> >]
Huang, Zih-You [> >]
Huang, Chi-Hsien [> >]
Wu, Shih-Hsiung [> >]
Lin, Mei-Hsiang [> >]
International Journal of Molecular Sciences
Molecular Diversity Preservation International (MDPI)
Yes (verified by ORBi)
[en] irradiation ; anti-cataract ; coumarin ; γ-crystallin ; iron-chelation
[en] Coumarin derivative 1, 5,7-dihydroxy-6-(3-methyl-1-butyryl)-4-phenyl-chromen- 2-one, has been reported to possess radical scavenging activity and DNA protection. We have synthesized a series of coumarins with structural modifications at positions C4, C5, C6 and C7 and evaluated them for their anti-UVC properties. Coumarin 7, 6-benzoyl-5,6-dihydroxy-4-phenyl-chromen-2-one, was found to have the most potent activity in protecting porcine γ-crystallin against UVC insults. Results of fluorescence assays indicated that compound 7 was capable of decreasing the loss of intensity while lens crystallins and DNA PUC19 were irradiated with UVC. Presence of compound 7 decreased hydroxyl radical levels determined by probe 1b and the free iron concentrations determined by Ferrozine reagent. The chelation assay showed that compound 7 was chelated to metal via 6-CO and 5-OH on the benzopyrone ring. The observed protective effects of compound 7 towards crystallins from insults of UVC and free radicals may be due to its iron-chelating activity and its peak absorption at 254 nm.
National Science Council (NSC98-2313-B-038-002-MY3) and Academia Sinica, Taipei, Taiwan

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