Trophoblast Invasion and Placentation: Molecular Mechanisms and Regulation

[en] Trophoblast invasion is a key process during human placentation. This event constitutes the basis of the conversion of the uterine spiral arteries, a process which allows an adequate vascular connection between the intervillous space and the maternal blood flow. Trophoblast invasion is transient, with stringent spatial and temporal control. Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is associated with decreased, shallow trophoblastic invasion. In this article, we review the molecular mechanisms of trophoblast invasion, and its mechanisms of regulation. Insights into the etiopathogenesis of preeclampsia will also be detailed.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

van den Brule, F.

Berndt, Sarah ; Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

Simon, N.

Coulon, C.

Le Goarant, J.

Munaut, Carine ; Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

Noël, Agnès ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme

Frankenne, Francis

Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique

Language :

English

Title :

Trophoblast Invasion and Placentation: Molecular Mechanisms and Regulation

Publication date :

2005

Journal title :

Chemical Immunology and Allergy

ISSN :

1660-2242

Publisher :

Karger, Switzerland

Volume :

Pages :

163-80

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 May 2009

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738 (8 by ULiège)

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