Article (Scientific journals)
Reduction of apoptosis and proliferation in endometriosis
Beliard, Aude; Noël, Agnès; Foidart, Jean-Michel
2004In Fertility and Sterility, 82 (1), p. 80-85
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Keywords :
endometriosis; cellular proliferation; apoptosis; estrogen receptor; progesterone receptor
Abstract :
[en] Objective: To evaluate whether endometriosis could be related to an impaired balance between apoptosis and proliferation, two processes which could be modulated by hormonal status. Design: Immunohistochemical study. Setting: Academic research laboratory. Intervention(s): Endometriotic samples obtained from peritoneum of women aged 26-40 years who were undergoing laparoscopy for pain or infertility. Main Outcome Measure(s): Apoptotic cells were detected with the use of the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. The production of p53 and bcl-2, estrogen and Progesterone (P) receptors, and cellular proliferation were assessed by immunohistochemistry in eutopic and ectopic endometria from 30 patients with endometriosis throughout the menstrual cycle. Results were compared with those from normal endometria from 15 fertile patients. Result(s): Endometriotic lesions were characterized by reduced TUNEL and p53 stainings and by enhanced bcl-2 staining. No correlation between apoptosis and estrogen receptor or P receptor levels was found. A lower amount of steroid receptor was found in endometriotic tissues, without cyclic modulation, compared with the eutopic endometrium. Conclusion(s): Our results suggest that when endometrial tissue is located at ectopic locations, it differs from eutopic endometrium by its proliferation rate, steroid hormone levels, and markers of apoptosis. A reduced sensitivity of endometriotic cells to apoptosis could promote the dissemination and implantation of these cells to ectopic sites. (C) 2004 by American Society for Reproductive Medicine.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Beliard, Aude ;  Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR
Noël, Agnès ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Language :
English
Title :
Reduction of apoptosis and proliferation in endometriosis
Publication date :
July 2004
Journal title :
Fertility and Sterility
ISSN :
0015-0282
eISSN :
1556-5653
Publisher :
Elsevier, New York, United States - New York
Volume :
82
Issue :
1
Pages :
80-85
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 May 2009

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