Genetic markers of osteoarticular disorders: facts and hopes.

Genetic Markers; Genetic Predisposition to Disease; Humans; Karyotyping; Molecular Biology; Osteoarthritis/complications/genetics/physiopathology; Osteoporosis/complications/genetics/physiopathology; Quantitative Trait, Heritable

Abstract :

[en] Osteoarthritis and osteoporosis are the two most common age-related chronic disorders of articular joints and skeleton, representing a major public health problem in most developed countries. Apart from being influenced by environmental factors, both disorders have a strong genetic component, and there is now considerable evidence from large population studies that these two disorders are inversely related. Thus, an accurate analysis of the genetic component of one of these two multifactorial diseases may provide data of interest for the other. However, the existence of confounding factors must always be borne in mind in interpreting the genetic analysis. In addition, each patient must be given an accurate clinical evaluation, including family history, history of drug treatments, lifestyle, and environment, in order to reduce the background bias. Here, we review the impact of recent work in molecular genetics suggesting that powerful molecular biology techniques will soon make possible both a rapid accumulation of data on the genetics of both disorders and the development of novel diagnostic, prognostic, and therapeutic approaches.

Disciplines :

General & internal medicine

Author, co-author :

Brandi, M L

Gennari, L

Cerinic, M M

Becherini, L

Falchetti, A

Masi, L

Gennari, C

REGINSTER, Jean-Yves ; Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur

Language :

English

Title :

Genetic markers of osteoarticular disorders: facts and hopes.

Publication date :

2001

Journal title :

Arthritis Research

ISSN :

1465-9905

eISSN :

1465-9913

Publisher :

BioMed Central, London, United Kingdom

Volume :

Issue :

Pages :

270-80

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 May 2012

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