Reference : Less vasoocclusive disease after intravenous ersus oral busulfan for autologous hemat...
Scientific journals : Article
Human health sciences : Hematology
Less vasoocclusive disease after intravenous ersus oral busulfan for autologous hematopoietic cell transplantation : the Belgian pediatric experience
Huybrechts, S. [> >]
BEGUIN, Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Ferster, A. [> >]
Laureys, G. [> >]
Uyttebroeck, A. [> >]
Vermeylen, C. [> >]
Belgian Journal of Hematology
Ariez Medical Publishing
The Netherlands
[en] autologous hematopoietic stem cell transplantation ; intravenous and oral busulfan ; combined regime ; children ; solid tumours ; veno-occlusive disease
[en] Busulfan is commonly used in preparative conditioning regimens prior to hematopoietic stem cell transplantation in children and young adults for malignant and non-malignant disorders. For many years Busulfan was only available in an oral form, resulting in large inter- and intra-patients variability in plasma exposure, associated with higher graft failure rate as well as higher toxicity such as venoocclusive disease. With the development of an intravenous formulation of Busulfan, a more accurate control of both the inter- and intra-patient variability has been provided. The goal of this study was to evaluate the use and efficacy of intravenous Busulfan in comparison with the oral formulation in children undergoing an autologous transplantation after conditioning with Busulfan. Despite the small number of patients, this study confirmed the apparent benefit of intravenous Busulfan in children undergoing an autologous HSCT. The use of a 5-level dose schedule defined by body weight resulted in an efficient engraftment with marked reduction in the incidence of veno-occlusive disease compared with oral Bu. In terms of diseasefree outcome, survival and event-free survival, similar results have been obtained in
both groups. The choice of this formulation of Busulfan should therefore be considered.

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