Reference : Aryl hydrocarbon receptor-interacting protein gene mutations in familial isolated pit...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/11949
Aryl hydrocarbon receptor-interacting protein gene mutations in familial isolated pituitary adenomas: analysis in 73 families.
English
Daly, Adrian [Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie >]
Vanbellinghen, Jean-François [Université de Liège - ULiège > > Centre de diagnostic moleculaire >]
Khoo, Sok Kean [> > > >]
Jaffrain-Rea, Marie-Lise [> > > >]
Naves, Luciana A [> > > >]
Guitelman, Mirtha A [> > > >]
Murat, Arnaud [> > > >]
Emy, Philippe [> > > >]
Gimenez-Roqueplo, Anne-Paule [> > > >]
Tamburrano, Guido [> > > >]
Raverot, Gerald [> > > >]
Barlier, Anne [> > > >]
De Herder, Wouter [> > > >]
Penfornis, Alfred [> > > >]
Ciccarelli, Enrica [> > > >]
Estour, Bruno [> > > >]
Lecomte, Pierre [> > > >]
Gatta, Blandine [> > > >]
Chabre, Olivier [> > > >]
Sabate, Maria Isabel [> > > >]
Bertagna, Xavier [> > > >]
Garcia Basavilbaso, Natalia [> > > >]
Stalldecker, Graciela [> > > >]
Colao, Annamaria [> > > >]
Ferolla, Piero [> > > >]
Wemeau, Jean-Louis [> > > >]
Caron, Philippe [> > > >]
Sadoul, Jean-Louis [> > > >]
Oneto, Adriana [> > > >]
Archambeaud, Francoise [> > > >]
Calender, Alain [> > > >]
Sinilnikova, Olga [> > > >]
Montanana, Carmen Fajardo [> > > >]
Cavagnini, Francesco [> > > >]
Hana, Vaclav [> > > >]
Solano, Angela [> > > >]
Delettieres, Dreanina [> > > >]
Luccio-Camelo, Douglas C [> > > >]
Basso, Armando [> > > >]
Rohmer, Vincent [> > > >]
Brue, T. [ > > ]
Bours, Vincent [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique générale et humaine >]
Teh, B. [ > > ]
Beckers, Albert mailto [Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie >]
May-2007
Journal of Clinical Endocrinology and Metabolism
Endocrine Society
92
5
1891-1896
Yes (verified by ORBi)
International
0021-972X
Chevy Chase
MD
[en] Adenoma/genetics/pathology ; Adult ; Aged ; Cohort Studies ; Female ; Gene Frequency ; Germ-Line Mutation/genetics ; Growth Hormone/metabolism ; Humans ; Immunohistochemistry ; Intracellular Signaling Peptides and Proteins ; Male ; Middle Aged ; Molecular Sequence Data ; Mutation/physiology ; Pituitary Neoplasms/genetics/pathology ; Prolactinoma/genetics/metabolism/pathology ; Proteins/genetics
[en] CONTEXT: An association between germline aryl hydrocarbon receptor-interacting protein (AIP) gene mutations and pituitary adenomas was recently shown. OBJECTIVE: The objective of the study was to assess the frequency of AIP gene mutations in a large cohort of patients with familial isolated pituitary adenoma (FIPA). DESIGN: This was a multicenter, international, collaborative study. SETTING: The study was conducted in 34 university endocrinology and genetics departments in nine countries. PATIENTS: Affected members from each FIPA family were studied. Relatives of patients with AIP mutations underwent AIP sequence analysis. MAIN OUTCOME MEASURES: Presence/absence and description of AIP gene mutations were the main outcome measures. INTERVENTION: There was no intervention. RESULTS: Seventy-three FIPA families were identified, with 156 patients with pituitary adenomas; the FIPA cohort was evenly divided between families with homogeneous and heterogeneous tumor expression. Eleven FIPA families had 10 germline AIP mutations. Nine mutations, R16H, G47_R54del, Q142X, E174frameshift, Q217X, Q239X, K241E, R271W, and Q285frameshift, have not been described previously. Tumors were significantly larger (P = 0.0005) and diagnosed at a younger age (P = 0.0006) in AIP mutation-positive vs. mutation-negative subjects. Somatotropinomas predominated among FIPA families with AIP mutations, but mixed GH/prolactin-secreting tumors, prolactinomas, and nonsecreting adenomas were also noted. Approximately 85% of the FIPA cohort and 50% of those with familial somatotropinomas were negative for AIP mutations. CONCLUSIONS: AIP mutations, of which nine new mutations have been described here, occur in approximately 15% of FIPA families. Although pituitary tumors occurring in association with AIP mutations are predominantly somatotropinomas, other tumor types are also seen. Further study of the impact of AIP mutations on protein expression and activity is necessary to elucidate their role in pituitary tumorigenesis in FIPA.
Researchers ; Professionals
http://hdl.handle.net/2268/11949
10.1210/jc.2006-2513
Cet article a bénéficié d'un éditorial de : S. Melmed - University of California - Los Angeles. Aryl Hydrocarbon Receptor Interacting Protein and Pituitary Tumorigenesis : Another Interesting Protein Editorial publié dans J. Clin. Endocrinol. Metab., vol 92 ; n°5 2007 : 1617-1619.

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Aryl hydrocarbon.pdfNo commentaryPublisher postprint109.78 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.