[en] Hair shedding and hair thinning have been reported to be affected by dandruff and seborrhoeic dermatitis. The present study was conducted in 150 men presenting with telogen effluvium related to androgenic alopecia associated with dandruff. They were randomly allocated to three groups receiving each one of the three shampoos in the market containing either 1% ketoconazole (KTZ), 1% piroctone olamine (PTO) or 1% zinc pyrithione (ZPT). Shampoos had to be used 2-3 times a week for 6 months. Hair shedding during shampoo was evaluated semiquantitatively. Hair density on the vertex was evaluated on photographs using a Dermaphot. Trichograms were used for determining the anagen hair percentage and the mean proximal hair shaft diameter using computerized image analysis. The sebum excretion rate (SER, mug cm(-2) h(-1)) was also measured using a Sebumeter((R)). The three treatments cleared pruritus and dandruff rapidly. At end point, hair density was unchanged, although hair shedding was decreased (KTZ: -17.3%, PTO: -16.5%, ZPT: -10.1%) and the anagen hair percentage was increased (KTZ: 4.9%, PTO: 7.9%, ZPT: 6.8%). The effect on the mean hair shaft diameter was contrasted between the three groups of volunteers (KTZ: 5.4%, PTO: 7.7%, ZPT: -2.2%). In conclusion, telogen effluvium was controlled by KTZ, PTO and ZPT shampoos at 1% concentration. In addition, KTZ and PTO increased the mean hair shaft thickness while discretely decreasing the sebum output at the skin surface.
Disciplines :
Dermatology
Author, co-author :
Franchimont, Claudine ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Goffin, Véronique ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Henry, Frédérique ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Uhoda, I.; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Braham, C.; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Language :
English
Title :
Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations.
Piérard-Franchimont, C. and Piérard, G.E. A propos du follicule pileux et du cycle pilaire: Considérations récentes. Rev. Med. Liège 52, 671-674 (1997).
Courtois, M., Loussouarn, G., Hourseau, S. and Grollier, J.F. Periodicity in the growth and shedding of hair. Br. J. Dermatol. 134, 47-54 (1996).
Stenn, K.S. Growth of the hair follicle: A cycling and regenerating biological system. In: Molecular Basis of Epithelial Appendage Morphogenesis (C.M. Chuong, ed.), pp.111-124. Landes Biosciences, Austin (1998).
Piérard-Franchimont, C. and Piérard, G.E. Teloptosis, a turning point in hair shedding biorythms. Dermatology 203, 115-117 (2001).
Stenn, K.S., Nixon, A.J., Jahoda, C.A.B., McKay, I.A. and Paus, R. What controls hair follicle cycling? Exp. Dermatol. 8, 229-236 (1999).
Van Steensel, M.A.M., Van Geel, M. and Seijjen, P.M. The molecular basis of hair growth. Eur. J. Dermatol. 11, 348-352 (2001).
Piérard, G.E. and de la Brassinne, M. Modulation of dermal cell activity during hair growth in the rat. J. Cutan. Pathol. 2, 35-41 (1975).
Paus, R., Mecklenburg, L. and Tobin, D.J. Active hair growth (anagen) is associated with angiogenesis. J. Invest. Dermatol. 114, 909-916 (2000).
Jaworsky, C., Kligman, A.M. and Murphy, G.F. Characterization of inflammatory infiltrates in male pattern alopecia: Implication for pathogenesis. Br. J. Dermatol. 127, 239-246 (1992).
Paus, R., Böttge, J.A., Henz, B.M. and Maurer, M. Hair growth control by immunosuppression. Arch. Dermatol. Res. 288, 408-410 (1996).
Piérard, G.E., Piérard-Franchimont, C., Nikkels-Tassoudji, N., Nikkels, A.F. and Saint Léger, D. Improvement in the inflammatory aspect of androgenetic alopecia. A pilot study with an antimicrobial lotion. J. Dermatol. Treat. 7, 153-157 (1966).
Bohm, M. and Luger, T.A.The pilosebaceous unit is part of the skin immune system. Dermatology 196, 76-79 (1998).
Piérard-Franchimont, C., De Doncker, P., Wallace, R., Cauwenbergh, G. and Piérard, G.E. Ketoconazole shampoo: Effect of long term use in androgenic alopecia. Dermatology 196, 474-488 (1998).
Christoph, T., Müller-Röver, S., Audring, H., et al. The human hair follicle immune system. Cellular composition and immune privilege. Br. J. Dermatol. 142, 862-872 (2000).
Mahé, Y.F., Michelet, J.F., Billoni, N., et al. Androgenic alopecia and microinflammation. Int. J. Dermatol. 39, 576-584 (2000).
Randall, V.A., Hibberts, N.A., Thornton, M.J., et al. The hair follicle: A paradoxical androgen target organ. Horm. Res. 54, 243-250 (2000).
Randall, V.A., Hibberts, N.A., Thornton, M.J., et al. Do androgens influence hair growth by altering the paracrine factors secreted bydermal papilla cells? Eur. J. Dermatol. 11, 304-308 (2001).
Sawaya, M.E., Keane, R.W., Blume-Peytavi, U., et al. Androgen responsive genes as they affect hair growth. Eur. J. Dermatol. 11, 315-320 (2001).
Piérard-Franchimont, C. and Piérard, G.E. L'effluvium télogène actinique: Une facette de la chronobiologie humaine. Int. J. Cosmet. Sci. 21, 15-21 (1999).
Rushton, D.H., Ramsey, I.D., Norris, M.J. and Gilkes, J.J.H. Natural progression of male pattern baldness in young men. Clin. Exp. Dermatol.16, 188-192 (1991).
Shuster, S. The aetiology of dandruff and the mode of action of therapeutic agents. Br. J. Dermatol. 111, 232-242 (1984).
Shuster, S. Dandruff, seborrhoeic dermatitis and Pityrosporum ovale. Cosmet Toilet. 103, 87-91 (1988).
McGrath, J. and Murphy, G.M. The control of seborrhoeic dermatitis and dandruff by antipityrosporal drugs. Drugs 41, 178-184 (1991).
Piérard-Franchimont, C., Arrese, J.E. and Piérard, G.E. Immunohistochemical aspects of the link between Malassezia ovalis and seborrhoeic dermatitis. J. Eur. Acad. Dermatol. 4, 14-19 (1995).
Hay, R.J. and Graham Brown, R.A.C. Dandruff and seborrhoeic dermatitis: Causes and management. Clin. Exp. Dermatol. 22, 3-6 (1997).
Kesavan, S., Walters, C.E., Holland, K.T. and Ingham, E. The effects of Malassezia on pro-inflammatory cytokine production by human peripheral blood mononuclear cells in vitro. Med. Mycol. 36, 97-106 (1998).
Piérard-Franchimont, C., Arrese, J.E., Durupt, G., Ries, G., Cauwenbergh, G. and Piérard, G.E. Correlation between Malassezia spp load and dandruff severity. J. Mycol. Med. 8, 83-86 (1998).
Faergemann, J. Management of seborrhoeic dermatitis and pityriasis versicolor. Am. J. Clin. Dermatol. 1, 75-80 (2000).
Loden, M. and Wessman, C. The antidandruff efficacy of a shampoo containing piroctone olamine and salicylic acid in comparison to that of a zinc pyrithione shampoo. Int. J. Cosmet Sci. 22, 285-289 (2000).
Piérard-Franchimont, C., Hermanns, J.F., Degreef, H. and Piérard, G.E. Axioms to new insights into dandruff. Dermatology 200, 93-98 (2000).
Ford, G.P., Farr, P.M., Ive, F.A. and Shuster, S. The response of seborrhoeic dermatitis to ketoconazole. Br. J. Dermatol.111, 603-607 (1984).
Arrese, J, Piérard-Franchimont, C, De Doncker, P, Heremans, A, Cauwenbergh, G. and Piérard, G.E. Effect of ketoconazole medicated shampoos on squamometry and Malassezia ovalis load in pityriasis capitis. Cutis 58, 235-237 (1996).
Heng, M.C.Y., Henderson, C.L., Barker, D.C. and Haberfelde, G. Correlation of Pityrosporum ovale density with clinical severity of seborrhoeic dermatitis as assessed by a simplified technique. J. Am. Acad. Dermatol. 23, 82-86 (1990).
Piérard, G.E., Arrese, J.E., Piérard-Franchimont, C. and De Doncker, P. Prolonged effect of antidandruff shampoos. Time to recurrence of Malassezia ovalis colonization of skin. Int. J. Cosmet. Sci. 19, 111-117 (1997).
Watanabe, S., Kano, R., Sato, H., Nakamura, Y. and Hasegawa, A. The effects of Malassezia yeasts on cytokine production by human keratinocytes. J. Invest. Dermatol. 116, 769-773 (2001).
Piérard-Franchimont, C. and Piérard, G.E. Approche physiopathologique de la séborhée du cuir chevelu. Ann. Dermatol. Venereol. 115, 451-453 (1988).
Piérard, G.E., Piérard-Franchimont, C., Marks, R., Paye, M. and Rogiers, V. the EEMCO group. EEMCO guidance for the in vivo assessment of skin greasiness. Skin Pharmacol. Appl. Skin Physiol.13, 372-389 (2000).
Zouboulis, C. Human skin: An independent peripheral endocrine organ. Horm. Res. 54, 230-242 (2000).
De Lacharrière, O., Deloche, C., Misciali, C., et al. Hair diameter diversity. Aclinical sign reflecting the follicle miniaturization. Arch. Dermatol. 137, 641-646 (2001).
Chronnell, C.M., Ghali, R.S., Quinn, A.G., et al. Human beta defensin-1 and -2 expression in human pilosebaceous units: Up-regulation in acne vulgaris lesions. J. Invest. Dermatol.117, 1120-1125 (2001).
