Reference : Verotoxigenic Escherichia coli from animals, humans and foods: who's who?
Scientific journals : Article
Life sciences : Microbiology
Verotoxigenic Escherichia coli from animals, humans and foods: who's who?
Mainil, Jacques mailto [Université de Liège - ULiège > Maladies infectieuses et parasitaires > Bactériologie et pathologie des maladies bactériennes > >]
Daube, Georges mailto [Université de Liège - ULiège > Sciences des Denrées alimentaires > Microbiologie des denrées alimentaires >]
Journal of Applied Microbiology
Blackwell Publishing Ltd
Yes (verified by ORBi)
[en] VTEC ; EHEC ; Food ; Animal ; Human ; Virulence
[en] Verocytotoxigenic (shigatoxigenic) and enterohaemorrhagic Escherichia coli, VTEC ( STEC) and EHEC, produce a toxin active on Vero cells in vitro. VTEC and EHEC have been isolated from humans and different animal species, mainly ruminants and pigs. The verocytotoxins, also named shiga toxins (Stx), are active in vivo on the endothelial cells of the blood vessels of the gastro-intestinal mucosa, the kidneys, the brain, and other tissues of humans and piglets, leading to fluid leakage or haemorrhages. Conversely, their role in diseases of young ruminants remains unclear. Adult ruminants can also act as asymptomatic carriers of VTEC and EHEC strains similar to those causing diseases in humans. And they are incriminated as an important source of direct or indirect contamination of humans by the most famous EHEC strain belonging to the O157: H7 serotype, through faecal contamination of either foods of animal origin, or other foodstuffs ( fruit, vegetables, etc.), or the environment. But dozens of non-O157 human and ruminant VTEC and EHEC strains with similar general and virulence-associated properties, have been described, whose epidemiology is much less well understood. The purpose of this review manuscript is to describe and compare the properties of human, ruminant and food VTEC and EHEC strains.
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