Article (Scientific journals)
Number and relative size of thenar motor units in ALS patients: application of the adapted multiple point stimulation method.
Wang, François-Charles; Delwaide, Paul
1998In Electroencephalography and Clinical Neurophysiology, 109 (1), p. 36-43
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Keywords :
Adult; Aged; Amyotrophic Lateral Sclerosis/physiopathology; Electric Stimulation; Electromyography; Female; Humans; Male; Middle Aged; Muscles/physiopathology; Reproducibility of Results
Abstract :
[en] In the present study, the adapted multiple point stimulation (AMPS) method was first applied to median innervated thenar muscles in 22 amyotrophic lateral sclerosis (ALS) patients who did not received any treatment. In all patients, a motor unit number estimate (MUNE) and an average surface-recorded motor unit action potential (S-MUAP) size have been derived even if the denervation was severe; and the results were reproducible. The thenar MUNE was less than the normal lower limit for age in 17 patients, and the mean MUNE (67.1 +/- 90.6) was significantly different from that estimated in control subjects (263.3 +/- 116.8). The mean S-MUAP size in the 22 ALS patients was 352.9 +/- 328.4 microV x ms versus 94.1 +/- 30.3 microV x ms in healthy volunteers. A control AMPS was achieved in 8 patients after 2 and 6 months of a glutamate-release antagonist (riluzole) treatment. The mean loss of motor units, based on control thenar MUNEs realized after 6 months of treatment, was 53%. In conclusion, we propose AMPS as a manageable, reproducible and non-invasive procedure which permits one to quantify peripheral denervation and to appreciate the effectiveness of collateral reinnervation in ALS patients.
Disciplines :
Neurology
Author, co-author :
Wang, François-Charles  ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
Delwaide, Paul ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Number and relative size of thenar motor units in ALS patients: application of the adapted multiple point stimulation method.
Publication date :
1998
Journal title :
Electroencephalography and Clinical Neurophysiology
ISSN :
0013-4694
Publisher :
Elsevier, Limerick, Ireland
Volume :
109
Issue :
1
Pages :
36-43
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 April 2012

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