Analysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms.

Wang, Xingjun; Tromp, G.; Cole, C. W.; VERLOES, Alain; SakalihasanN, Natzi; Yoon, S.; Kuivaniemi, H.

doi:10.1016/S0945-053X(99)00008-6

Article (Scientific journals)

Analysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms.

Wang, Xingjun; Tromp, G.; Cole, C. W. et al.

1999 • In Matrix Biology, 18 (2), p. 121-4

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/116573

DOI
10.1016/S0945-053X(99)00008-6

PubMed
10372551

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Keywords :

Alleles; Aortic Aneurysm, Abdominal/genetics; Female; Gene Frequency; Genetic Variation; Humans; Male; Tissue Inhibitor of Metalloproteinase-1/genetics; Tissue Inhibitor of Metalloproteinase-2/genetics

Abstract :

[en] Aneurysms are characterized by dilation, i.e. expansion and thinning of all the arterial wall layers, which is accompanied by remodeling of the connective tissue. Genes involved in the regulation of tissue remodeling are therefore candidate genes. We analyzed TIMP1 and TIMP2 coding sequences in 12 individuals with abdominal aortic aneurysms (AAA), one individual with AAA and intracranial aneurysms (IA), four individuals with IA and two clinically unaffected individuals. We identified two nucleotide variants in both the TIMP1 and the TIMP2 coding sequences. All differences occurred in the third base positions of codons and were neutral polymorphisms. A significant difference was observed in the frequency of TIMP2 nt 573 polymorphism between 168 alleles from AAA patients and 102 control alleles.

Disciplines :

Surgery

Author, co-author :

Wang, Xingjun ; Université de Liège - ULiège > Département d'aérospatiale et mécanique > Computational & Multiscale Mechanics of Materials (CM3)

Tromp, G.

Cole, C. W.

VERLOES, Alain ; Centre Hospitalier Universitaire de Liège - CHU > Génétique

SakalihasanN, Natzi ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire

Yoon, S.

Kuivaniemi, H.

Language :

English

Title :

Analysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms.

Publication date :

1999

Journal title :

Matrix Biology

ISSN :

0945-053X

eISSN :

1569-1802

Publisher :

Gustav Fischer Verlag, Stuttgart, Germany

Volume :

Issue :

Pages :

121-4

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 13 April 2012

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Bibliography

Bardien S., Ebenezer N., Greenberg J.et al. An eighth locus for autosomal dominant retinitis pigmentosa is linked to chromosome 17q. Hum. Mol. Genet. 4:1995;1459-1462.
Bramhall S.R., Neoptolemos J.P., Stamp G.W., Lemoine N.R. Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma. J. Pathol. 182:1997;347-355.
Docherty A.J.P., Lyons A., Smith B.J., Wright E.M., Stephens P.E., Harris T.J.R. Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature (London). 7:1985;66-69.
Hammani K., Blakis A., Morsette D.et al. Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene. J. Biol. Chem. 271:1996;25498-25505.
Kuivaniemi H., Prokop D.J., Wu Y.et al. Exclusion of mutations in the gene for type III collagen (COL3A1) as a common cause of intracranial aneurysms or cervical artery dissections by sequence analysis of the coding sequences of type III collagen from 55 unrelated patients. Neurology. 43:1993;2652-2658.
Olson T.M., Hirohata S., Ye J., Leco K., Seldin M.F., Apte S.S. Cloning of the tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosomes 3p25 and mouse chromosome 6, respectively. Genomics. 51:1998;148-151.
Ronkainen A., Hernesniemi J., Puranen M.et al. Familial intracranial aneurysms. Lancet. 349:1997;380-384.
Stetler-Stevenson W.G., Brown P.D., Onisto M., Levy A.T., Liotta L.A. Tissue inhibitor of metalloproteinases-2 (TIMP2) mRNA expression in tumor cell lines and human tumor tissues. J. Biol. Chem. 265:1990;13933-13938.
Tamarina N.A., McMillan W.D., Shively V.P., Pearce W.H. Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta. Surgery. 122:1997;264-271.
Tilson M.D., Reilly J.M., Brophy C.M., Webster E.L., Barnett T.R. Expression and sequence of the gene for tissue inhibitor of metalloproteinases in patients with abdominal aortic aneurysms. J. Vasc. Surg. 18:1993;266-270.
Tromp G., Wu Y., Prockop D.J.et al. Sequencing of cDNA from 50 unrelated patients reveals that mutations in the triple-helical domain of type III procollagen are an infrequent cause of aortic aneurysms. J. Clin. Invest. 91:1993;2539-2545.
Verloes A., Sakalihasan N., Limet R., Koulischer L. Genetic aspects of abdominal aortic aneurysms. Ann. N.Y. Acad. Sci. 800:1996;44-55.