Reference : Analysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP1) and...
Scientific journals : Article
Human health sciences : Surgery
Analysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms.
Wang, Xingjun mailto [Université de Liège - ULiège > Département d'aérospatiale et mécanique > Computational & Multiscale Mechanics of Materials (CM3)]
Tromp, G. [> > > >]
Cole, C. W. [> > > >]
VERLOES, Alain mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique]
SakalihasanN, Natzi mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire]
Yoon, S. [> > > >]
Kuivaniemi, H. [> > > >]
Matrix Biology
Gustav Fischer Verlag
Yes (verified by ORBi)
[en] Alleles ; Aortic Aneurysm, Abdominal/genetics ; Female ; Gene Frequency ; Genetic Variation ; Humans ; Male ; Tissue Inhibitor of Metalloproteinase-1/genetics ; Tissue Inhibitor of Metalloproteinase-2/genetics
[en] Aneurysms are characterized by dilation, i.e. expansion and thinning of all the arterial wall layers, which is accompanied by remodeling of the connective tissue. Genes involved in the regulation of tissue remodeling are therefore candidate genes. We analyzed TIMP1 and TIMP2 coding sequences in 12 individuals with abdominal aortic aneurysms (AAA), one individual with AAA and intracranial aneurysms (IA), four individuals with IA and two clinically unaffected individuals. We identified two nucleotide variants in both the TIMP1 and the TIMP2 coding sequences. All differences occurred in the third base positions of codons and were neutral polymorphisms. A significant difference was observed in the frequency of TIMP2 nt 573 polymorphism between 168 alleles from AAA patients and 102 control alleles.

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