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Does cognitive impairment influence burden in caregivers of patients with Alzheimer’s disease?

Germain, Sophie; Adam, Stéphane; Olivier, Catherine et al.

2009 • In Journal of Alzheimer's Disease, 17 (1), p. 105-114

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https://hdl.handle.net/2268/11576

DOI
10.3233/JAD-2009-1016

PubMed
19494435

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Keywords :

Alzheimer; burden; Caregivers; cognitive impairment; behavioral symptoms; activities of daily living

Abstract :

[en] Alzheimer's disease is characterized by a progressive deterioration of various cognitive and behavioral abilities and it also has a health impact on the patients’ caregiver. Our aim was to determine the patient (and to a lesser extent the caregiver’s) characteristics that contribute most to the caregiver burden. We used the baseline data from the ICTUS study, a European longitudinal cohort of patients with mild to moderate AD. Data from 1091 patients and their caregivers has been used for analysis. Three principal components analyses were performed on variables from the domains of cognition, neuropsychiatric symptoms and daily function using MMSE plus ADAS-Cog, NPI and IADL subscores respectively. These were followed by a stepwise logistic regression to identify patient characteristics which best predict caregiver burden. The regression model (R2 = 0.35, p < .001) shows that the best explanatory variables are (1) neuropsychiatric symptoms (NPI), (2) difficulties in the IADL, (3) time taken by caregiving, (4) demographic variables such as caregiver’s age and patient sex and (5) severity of cognitive impairment. In conclusion, our results demonstrate that although the strongest determinant of the caregiver burden is behavioral disturbance, the impact of the degree of cognitive impairment on burden is also significant.

Research Center/Unit :

Centre de la Mémoire CHU de Liège

Disciplines :

Neurosciences & behavior

Author, co-author :

Germain, Sophie ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie

Adam, Stéphane ; Université de Liège - ULiège > Services généraux (Fac. de psycho. et des sc. de l'éducat.) > Service administratif de la Fac. (Psycho et sc. éducation)

Olivier, Catherine ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman

Cash, Helen

Ousset, Pierre Jean

Andrieu, Sandrine

Vellas, Bruno

Meulemans, Thierry ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie

Reynish, Emma

Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.

Language :

English

Title :

Does cognitive impairment influence burden in caregivers of patients with Alzheimer’s disease?

Publication date :

2009

Journal title :

Journal of Alzheimer's Disease

ISSN :

1387-2877

eISSN :

1875-8908

Publisher :

IOS Press

Volume :

17

Issue :

1

Pages :

105-114

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

EADC - European Alzheimer's Disease Consortium

Available on ORBi :

since 20 April 2009

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