Reference : Does cognitive impairment influence burden in caregivers of patients with Alzheimer’s...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Does cognitive impairment influence burden in caregivers of patients with Alzheimer’s disease?
Germain, Sophie mailto [Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie >]
Adam, Stéphane mailto [Université de Liège - ULiège > Services généraux (Fac. de psycho. et des sc. de l'éducat.) > Service administratif de la Fac. (Psycho et sc. éducation) >]
Olivier, Catherine [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Cash, Helen [ > > ]
Ousset, Pierre Jean [ > > ]
Andrieu, Sandrine [ > > ]
Vellas, Bruno [ > > ]
Meulemans, Thierry mailto [Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie >]
Reynish, Emma [ > > ]
Salmon, Eric mailto [Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Journal of Alzheimer's Disease [=JAD]
IOS Press
Yes (verified by ORBi)
[en] Alzheimer ; burden ; Caregivers ; cognitive impairment ; behavioral symptoms ; activities of daily living
[en] Alzheimer's disease is characterized by a progressive deterioration of various cognitive and behavioral abilities and it also has a health impact on the patients’ caregiver. Our aim was to determine the patient (and to a lesser extent the caregiver’s) characteristics that contribute most to the caregiver burden.
We used the baseline data from the ICTUS study, a European longitudinal cohort of patients with mild to moderate AD. Data from 1091 patients and their caregivers has been used for analysis.
Three principal components analyses were performed on variables from the domains of cognition, neuropsychiatric symptoms and daily function using MMSE plus ADAS-Cog, NPI and IADL subscores respectively. These were followed by a stepwise logistic regression to identify patient characteristics which best predict caregiver burden.
The regression model (R2 = 0.35, p < .001) shows that the best explanatory variables are (1) neuropsychiatric symptoms (NPI), (2) difficulties in the IADL, (3) time taken by caregiving, (4) demographic variables such as caregiver’s age and patient sex and (5) severity of cognitive impairment.
In conclusion, our results demonstrate that although the strongest determinant of the caregiver burden is behavioral disturbance, the impact of the degree of cognitive impairment on burden is also significant.
Centre de la Mémoire CHU de Liège
European Alzheimer Disease Consortium
Researchers ; Professionals ; Students

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