[en] The purpose of this study was to investigate the possible role of the cholinergic pathway in mediating platelet-activating factor (PAF)-induced pulmonary dysfunctions in unsedated calves. In a placebo group, PAF infusion challenge induced significant dysfunctions in the pattern of breathing [a significant increase in respiratory rate (RR) and a significant decrease in tidal volume (VT)], the mechanics of breathing [a significant increase in total lung resistance (RL) and a significant decrease in dynamic lung compliance (CLdyn)] and gas exchange, whereas in atropine pre-treated calves, PAF infusion challenge induced a significant increase in RR, VT and HR and a significant decrease in CLdyn. The RL increase was prevented by atropine pre-treatment. On the basis of our findings, we suggest that, in cattle, the PAF-induced pattern of breathing dysfunctions and the diffuse bronchoconstriction and microvascular leakage of small airways are not mediated through the cholinergic pathway. By contrast, our data suggest that PAF-induced bronchoconstriction of upper airways is at least partly mediated through muscarinic receptors.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Van de Weerdt, ML; Université de Liège - ULiège > Faculté de Médecine vétérinaire
Husson, Cécile; Université de Liège - ULiège > Faculté de Médecine vétérinaire
Lekeux, Pierre ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
Language :
English
Title :
Role of the cholinergic pathway in mediating platelet-Activating factor-induced pulmonary dysfunctions in unsedated calves
Publication date :
1999
Journal title :
Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine
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