Effect of biologically active coating on biocompatibility of Nitinol devices designed for the closure of intra-atrial communications.

Kong, Xiangqing; Grabitz, R. G.; van Oeveren, W.; Klee, D.; van Kooten, T. G.; Freudenthal, F.; Qing, Ma; von Bernuth, G.; SEGHAYE, Marie-Christine

doi:10.1016/S0142-9612(01)00304-0

Article (Scientific journals)

Effect of biologically active coating on biocompatibility of Nitinol devices designed for the closure of intra-atrial communications.

Kong, Xiangqing; Grabitz, R. G.; van Oeveren, W. et al.

2002 • In Biomaterials, 23 (8), p. 1775-83

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/112969

DOI
10.1016/S0142-9612(01)00304-0

PubMed
11950048

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Keywords :

Alloys/chemistry; Animals; Biocompatible Materials; Blood Platelets/metabolism; Cells, Cultured; Endothelium, Vascular/cytology/metabolism; Fibronectins/chemistry; Hemolysis; Heparin/chemistry; Hirudins/chemistry; Humans; Immunohistochemistry; Microscopy, Confocal; Microscopy, Electron, Scanning; Partial Thromboplastin Time; Sheep; Tetrazolium Salts/pharmacology; Thiazoles/pharmacology; Umbilical Veins/metabolism

Abstract :

[en] Anti-thrombogenicity and rapid endothelialisation are prerequisites for the use of closure devices of intra-atrial communications in order to reduce the risk of cerebral embolism. The purpose of this study was therefore to assess the effect of bioactive coatings on biocompatibility of Nitinol coils designed for the closure of intra-atrial communications. Nitinol coils (n = 10, each) and flat Nitinol bands (n = 3, each) were treated by basic coating with poly(amino-p-xylylene-co-p-xylylene) and then coated with either heparin, r-hirudin or fibronectin. Anti-thrombogenicity was studied in vitro in a dynamic model with whole blood by partial thromboplastin time (PTT), platelet binding and thrombin generation, respectively, and cytotoxicity by hemolysis. Endothelialisation was studied on Nitinol bands with human umbilical venous endothelial cells (HUVEC) by 3-(4,5-dimethylthiazole-2yl)-2,5-triphenyl tetrazolium (MTT) assay and immnuofluorescence analysis of Ki67, vinculin, fibronectin and von Willebrand Factor. Uncoated or coated devices did not influence hemolysis and PTT. r-Hirudin (but not heparin) and fibronectin coating showed lower platelet binding than uncoated Nitinol (p < 0.005, respectively). Heparin and r-hirudin coating reduced thrombin formation (p < 0.05 versus Nitinol, respectively). HUVEC adhesion, proliferation, and matrix formation decreased in the order: fibronectin coating > uncoated Nitinol > r-hirudin coating > heparin coating > basic coating. MTT assay corroborated these findings. In conclusion, r-hirudin and fibronectin coating, by causing no acute cytotoxicity, decreasing thrombogenicity and increasing endothelialisation improve in vitro biocompatibility of Nitinol devices designed for the closure of intra-atrial communications.

Disciplines :

Pediatrics
Laboratory medicine & medical technology

Author, co-author :

Kong, Xiangqing; Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > Pediatric Cardiology

Grabitz, R. G.; Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > Pediatric Cardiology

van Oeveren, W.; University of Groningen, The Netherlands > Biomedical Engineering

Klee, D.; Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > Institute of Macromolecular- and Textile Chemistry

van Kooten, T. G.; University of Groningen, The Netherlands > Biomedical Engineering

Freudenthal, F.; Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > Pediatric Cardiology

Qing, Ma; Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > Pediatric Cardiology

von Bernuth, G.; Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > Pediatric Cardiology

SEGHAYE, Marie-Christine ; Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > Pediatric Cardiology

Language :

English

Title :

Effect of biologically active coating on biocompatibility of Nitinol devices designed for the closure of intra-atrial communications.

Publication date :

April 2002

Journal title :

Biomaterials

ISSN :

0142-9612

eISSN :

1878-5905

Publisher :

Butterworth Heinemann, Oxford, United Kingdom

Volume :

Issue :

Pages :

1775-83

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 27 February 2012

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