[en] How the Human T lymphotropic virus type 1 (HTLV-1) Tax protein stimulates proliferation while triggering cell cycle arrest and senescence remains puzzling. There is also a debate about the ability of Tax to activate or inhibit the DNA damage response. Here, we comment on these different activities and propose a conceptual rationale for the apparently conflicting observations.
Disciplines :
Oncologie
Auteur, co-auteur :
Boxus, Mathieu ; Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Willems, Luc ; Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Langue du document :
Anglais
Titre :
How the DNA damage response determines the fate of HTLV-1 Tax-expressing cells
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