SHIP2 et signalisation de l'insuline: quel role dans la pathogenese et le traitement du diabete de type 2?

Based on the analysis of SHIP2+/- and SHIP2-/- mice showing that the lipid phophatase SHIP2 is an important negative regulator of the insulin pathway, we have suggested that the enzyme is a candidate gene for genetic predisposition to type 2 diabetes, and a potential therapeutic target for the same disease. Two years after, we propose to review these hypothesis in light of recent results from our laboratory, from international collaborations and from competitors in the field.