[en] Few studies have been performed to assess the risk of skin damage by cyclodextrins (CD) and they have yielded contradictory results. The present study was conducted using the corneoxenometry bioassay on human stratum corneum to compare the skin compatibility of CD currently used in pharmaceutical preparations (betaCD, gammaCD, Rameb, Dimeb, Trimeb, HP-betaCD and HP-gammaCD) and that of new amphiphilic CD derivatives, namely, the phospholipidyl-CD (DMPE-Dimeb and DMPE-Trimeb). All the tested CD were well tolerated by the stratum corneum at a concentration of 5%. However, inter-individual reactivity was larger for DMPE-Dimeb, suggesting a more aggressive trend for this compound. Cutaneous Index of Mildness values obtained confirm that Dimeb is able to extract some skin components and shows that DMPE-Dimeb performs similarly.
Disciplines :
Dermatology
Author, co-author :
Piel, Géraldine ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique et magistrale
Moutard, S.
Uhoda, Emmanuelle ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Pilard, F.
Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Perly, B.
Delattre, Luc ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Evrard, Brigitte ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Language :
English
Title :
Skin compatibility of cyclodextrins and their derivatives: a comparative assessment using a corneoxenometry bioassay.
Publication date :
2004
Journal title :
European Journal of Pharmaceutics and Biopharmaceutics
Lesieur S., Charon D., Lesieur P., Ringard C., Muguet V., Duchene D., Wouessidjewe D. Phase behavior of fully hydrated DMPC-amphiphilic cyclodextrin systems. Chem Phys Lipids. 106:2000;127-144.
Loftsson T., Masson M. Cyclodextrins in topical drug formulations: theory and practice. Int J Pharm. 225:2001;15-30.
Irie T., Uekama K. Pharmaceutical application of cyclodextrins. III. Toxicological issues and safety evaluation. J Pharm Sci. 86:1997;147-162.
Goffin V., Letawe C., Piérard G.E. Effect of organic solvents on normal human stratum corneum. Evaluation by corneoxenometry bioassay. Dermatology. 195:1997;321-324.
Piérard G.E., Goffin V., Piérard-Franchimont C. Corneosurfametry: a predictive assessment of the interaction of personal-care cleansing products with the human stratum corneum. Dermatology. 189:1994;152-156.
Goffin V., Piérard-Franchimont C., Piérard G.E. Shielded corneosurfametry and corneoxenometry: novel bioassays for the assessment of skin barrier products. Dermatology. 196:1998;434-437.
Goffin V., Henry F., Piérard-Franchimont C., Piérard G.E. Penetration enhancers assessed by corneoxenometry. Skin Pharmacol Appl Skin Physiol. 13:2000;280-284.
Goffin V., Piérard-Franchimont C., Piérard G.E. Sensitive skin and stratum corneum reactivity to household cleaning products. Contact Dermat. 34:1996;81-85.
Piérard G.E. EEMCO guidance for the assessment of skin colour. J Eur Acad Dermatol Venerol. 10:1998;1-11.
Moutard S., Perly B., Gode P., Demailly G., Djedaïni-Pilard F. Novel glycolipids based on cyclodextrins. J Inclu Phenom Macrocyclic Chem. 44:2002;317-322.
