Reference : Polymorphisms in Type-II SH2 domain-containing Inositol 5-Phosphatase (INPPL1, SHIP2)...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/11105
Polymorphisms in Type-II SH2 domain-containing Inositol 5-Phosphatase (INPPL1, SHIP2) are Associated with Physiological Abnormalities of the Metabolic Syndrome
English
Kaisaki, P. J. [University of Oxford, Oxford, UK > The Wellcome Trust Centre for Human Genetics > > >]
Delépine, M. [National Centre for Genotyping, Evry, France > > > >]
Woon, P. Y. [University of Oxford, Oxford, UK > The Wellcome Trust Centre for Human Genetics > > >]
Sebag-Montefiore, L. [University of Oxford, Oxford, UK > The Wellcome Trust Centre for Human Genetics > > >]
Wilder, S. P. [University of Oxford, Oxford, UK > The Wellcome Trust Centre for Human Genetics > > >]
Menzel, S. [University of Oxford, Oxford, UK > The Wellcome Trust Centre for Human Genetics > > >]
Vionnet, N. [National Centre for Genotyping, Evry, France > > > >]
Marion, E. [Université Libre de Bruxelles - ULB > Institut de Recherches en Biologie Humaine et Moléculaire > > >]
Riveline, J. P. [Service d’Endocrinologie-Diabétologie, CH Sud Francilien, Corbeil-Essonnes, France > > > >]
Charpentier, G. [4Service d’Endocrinologie-Diabétologie, CH Sud Francilien, Corbeil-Essonnes, France > > > >]
Schurmans, Stéphane mailto [Université de Liège - ULiège > Département de sciences fonctionnelles > Biochimie métabolique vétérinaire >]
Levy, J. C. [University of Oxford > Oxford Centre for Diabetes, Endocrinology and Metabolism > > >]
Lathrop, M. [National Centre for Genotyping, Evry, France > > > >]
Farrall, M. [University of Oxford > Department of Cardiovascular Medicine > > >]
Gauguier, D. [University of Oxford, Oxford, UK > The Wellcome Trust Centre for Human Genetics > > >]
2004
Diabetes
American Diabetes Association
53
1900-1904
Yes (verified by ORBi)
International
0012-1797
1939-327X
Alexandria
VA
[en] Polymorphisms ; INPPL1 ; SHIP2 ; Metabolic Syndrome ; Physiological Abnormalities
[en] Type II SH2 domain-containing inositol 5-phosphatase (INPPL1, or SHIP2) plays an important role in the control of insulin sensitivity. INPPL1 mutations affecting gene function have been found in rat models of type 2 diabetes and hypertension and in type 2 diabetic patients. We investigated the influence of nucleotide variation in INPPL1 on components of the metabolic syndrome. Following comprehensive resequencing of the gene, we genotyped 12 informative polymorphisms in 1,304 individuals from 424 British type 2 diabetes families that were characterized for several metabolic phenotypes. We have found highly significant associations of single nucleotide polymorphisms (SNPs) and haplotypes of INPPL1 with hypertension as well as with other components of the metabolic syndrome. In a cohort of 905 French type 2 diabetic patients, we found evidence of association of INPPL1 SNPs with the presence of hypertension. We conclude that INPPL1 variants may impact susceptibility to disease and/or to subphenotypes involved in the metabolic syndrome in some diabetic patients
The Wellcome Trust (057733), the Wellcome Cardiovascular Functional Genomics Initiative (066780/Z/01/Z), and Diabetes U.K. (RD96/0001270)
Researchers ; Professionals
http://hdl.handle.net/2268/11105
10.2337/diabetes.53.7.1900

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