D. Sodi-Pallares, M.R. Testelli, B.L. Fishleder, A. Bisteni, G.A. Medrano, and C. Friedland Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infection. A preliminary clinical report Am J Cardiol 9 1962 166 181
R.A. Kloner, and R.W. Nesto Glucose-insulin-potassium for acute myocardial infarction: continuing controversy over cardioprotection Circulation 117 2008 2523 2533
M.A. Puskarich, M.S. Runyon, S. Trzeciak, J.A. Kline, and A.E. Jones Effect of glucose-insulin-potassium infusion on mortality in critical care settings: a systematic review and meta-analysis J Clin Pharmacol 49 2009 758 767
L.H. Opie Metabolic management of acute myocardial infarction comes to the fore and extends beyond control of hyperglycemia Circulation 117 2008 2172 2177
G. Van den Berghe, P. Wouters, F. Weekers, C. Verwaest, F. Bruyninckx, and M. Schetz Intensive insulin therapy in the critically ill patients N Engl J Med 345 2001 1359 1367
Z. Szabo, E. Hakanson, T. Maros, and R. Svedjeholm High-dose glucose-insulin-potassium after cardiac surgery: a retrospective analysis of clinical safety issues Acta Anaesthesiol Scand 47 2003 383 390
E.W. Boyer, and M. Shannon Treatment of calcium-channel-blocker intoxication with insulin infusion N Engl J Med 344 2001 1721 1722
C. Beauloye, L. Bertrand, U. Krause, A.S. Marsin, T. Dresselaers, and F. Vanstapel No-flow ischemia inhibits insulin signaling in heart by decreasing intracellular pH Circ Res 88 2001 513 519
D. De Villalobos, and H. Taegtmeyer Metabolic support for the postischaemic heart Lancet 345 1995 1552 1555
X. Du, D. Edelstein, S. Obici, N. Higham, M.H. Zou, and M. Brownlee Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation J Clin Invest 116 2006 1071 1080
J.D. Symons, S.L. McMillin, C. Riehle, J. Tanner, M. Palionyte, and E. Hillas Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure Circ Res 104 2009 1085 1094
N.A. Ali, J.M. O'Brien Jr., K. Dungan, G. Phillips, C.B. Marsh, and S. Lemeshow Glucose variability and mortality in patients with sepsis Crit Care Med 36 2008 2316 2321
G. Van den Berghe How does blood glucose control with insulin save lives in intensive care? J Clin Invest 114 2004 1187 1195
J.A. Kim, Y. Wei, and J.R. Sowers Role of mitochondrial dysfunction in insulin resistance Circ Res 102 2008 401 414
L. Ji, F. Fu, L. Zhang, W. Liu, X. Cai, and L. Zhang Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress Am J Physiol Endocrinol Metab 298 2010 E871 E880
I. Vanhorebeek, R. De Vos, D. Mesotten, P.J. Wouters, C. Wolf-Peeters, and B.G. Van den Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients Lancet 365 2005 53 59
K. Kuboki, Z.Y. Jiang, N. Takahara, S.W. Ha, M. Igarashi, and T. Yamauchi Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin Circulation 101 2000 676 681
F. Gao, E. Gao, T.L. Yue, E.H. Ohlstein, B.L. Lopez, and T.A. Christopher Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation Circulation 105 2002 1497 1502
L.J. Klein, C.M. van Campen, G.T. Sieswerda, O. Kamp, and F.C. Visser Effects of high-dose insulin infusion on left ventricular function in normal subjects Neth Heart J 18 2010 183 189
Z. Liu Insulin at physiological concentrations increases microvascular perfusion in human myocardium Am J Physiol Endocrinol Metab 293 2007 E1250 E1255
L.H. Clerk, M.A. Vincent, J.R. Lindner, M.G. Clark, S. Rattigan, and E.J. Barrett The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake Diabetes Metab Res Rev 20 2004 3 12
M.G. Clark Impaired microvascular perfusion: a consequence of vascular dysfunction and a potential cause of insulin resistance in muscle Am J Physiol Endocrinol Metab 295 2008 E732 E750
Gunduz D, Thom J, Hussain I, Lopez D, Hartel FV, Erdogan A, et al. Insulin stabilizes microvascular endothelial barrier function via phosphatidylinositol 3-kinase/Akt-mediated Rac1 activation. Arterioscler Thromb Vasc Biol 2010;30:1237-45.
P.B. Massion, O. Feron, C. Dessy, and J.L. Balligand Nitric oxide and cardiac function: ten years after, and continuing Circ Res 93 2003 388 398
P.B. Massion, C. Dessy, F. Desjardins, M. Pelat, X. Havaux, and C. Belge Cardiomyocyte-restricted overexpression of endothelial nitric oxide synthase (NOS3) attenuates beta-adrenergic stimulation and reinforces vagal inhibition of cardiac contraction Circulation 110 2004 2666 2672
F. Fath-Ordoubadi, and K.J. Beatt Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: an overview of randomized placebo-controlled trials Circulation 96 1997 1152 1156
A.G. Pittas, R.D. Siegel, and J. Lau Insulin therapy and in-hospital mortality in critically ill patients: systematic review and meta-analysis of randomized controlled trials JPEN J Parenter Enteral Nutr 30 2006 164 172
R. Diaz, E.A. Paolasso, L.S. Piegas, C.D. Tajer, M.G. Moreno, and R. Corvalan Metabolic modulation of acute myocardial infarction Circulation 98 1998 2227 2234
K. Malmberg, L. Ryden, S. Efendic, J. Herlitz, P. Nicol, and A. Waldenstrom Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year J Am Coll Cardiol 26 1995 57 65
J. Pache, A. Kastrati, J. Mehilli, H. Bollwein, G. Ndrepepa, and H. Schuhlen A randomized evaluation of the effects of glucose-insulin-potassium infusion on myocardial salvage in patients with acute myocardial infarction treated with reperfusion therapy Am Heart J 148 2004 e3
K. Malmberg, L. Ryden, H. Wedel, K. Birkeland, A. Bootsma, and K. Dickstein Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity Eur Heart J 26 2005 650 661
S.R. Mehta, S. Yusuf, R. Diaz, J. Zhu, P. Pais, and D. Xavier Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial JAMA 293 2005 437 446
R. Diaz, A. Goyal, S.R. Mehta, R. Afzal, D. Xavier, and P. Pais Glucose-insulin-potassium therapy in patients with ST-segment elevation myocardial infarction JAMA 298 2007 2399 2405
G.M. Coleman, S. Gradinac, H. Taegtmeyer, M. Sweeney, and O.H. Frazier Efficacy of metabolic support with glucose-insulin-potassium for left ventricular pump failure after aortocoronary bypass surgery Circulation 80 1989 I91 I96
J.D. Schipke, R. Friebe, and E. Gams Forty years of glucose-insulin- potassium (GIK) in cardiac surgery: a review of randomized, controlled trials Eur J Cardiothorac Surg. 29 2006 479 485
G.Y. Gandhi, M.H. Murad, D.N. Flynn, P.J. Erwin, A.B. Cavalcante, and N.H. Bay Effect of perioperative insulin infusion on surgical morbidity and mortality: systematic review and meta-analysis of randomized trials Mayo Clin Proc 83 2008 418 430
W. Bothe, M. Olschewski, F. Beyersdorf, and T. Doenst Glucose-insulin-potassium in cardiac surgery: a meta-analysis Ann Thorac Surg 78 2004 1650 1657
A. Nicolas-Robin, J. Amour, C. Ibanez-Esteve, P. Coriat, B. Riou, and O. Langeron Effect of glucose-insulin-potassium in severe acute heart failure after brain death Crit Care Med 36 2008 2740 2745
S.S. Hamdulay, A. Al Khafaji, and H. Montgomery Glucose-insulin and potassium infusions in septic shock Chest 129 2006 800 804
L.H. Opie, and J. Knuuti The adrenergic-fatty acid load in heart failure J Am Coll Cardiol 54 2009 1637 1646
J.C. Preiser, P. Devos, S. Ruiz-Santana, C. Melot, D. Annane, and J. Groeneveld A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study Intensive Care Med 35 2009 1738 1748
S. Finfer, D.R. Chittock, S.Y. Su, D. Blair, D. Foster, and V. Dhingra Intensive versus conventional glucose control in critically ill patients N Engl J Med 360 2009 1283 1297
G. Van den Berghe, P.J. Wouters, R. Bouillon, F. Weekers, C. Verwaest, and M. Schetz Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control Crit Care Med 31 2003 359 366
M. Kosiborod, S.E. Inzucchi, H.M. Krumholz, L. Xiao, P.G. Jones, and S. Fiske Glucometrics in patients hospitalized with acute myocardial infarction: defining the optimal outcomes-based measure of risk Circulation 117 2008 1018 1027
P.E. Marik, and J.C. Preiser Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis Chest 137 2010 544 551
Société franaise d'anesthésie et de réanimation/Société de réanimation de langue franaise Formal recommendations by the experts. Glycemic control in intensive care unit and during anaesthesia Ann Fr Anesth Reanim 28 2009 410 415
G.Y. Gandhi, G.A. Nuttall, M.D. Abel, C.J. Mullany, H.V. Schaff, and P.C. O'Brien Intensive intraoperative insulin therapy versus conventional glucose management during cardiac surgery: a randomized trial Ann Intern Med 146 2007 233 243
L. Groban, J. Butterworth, C. Legault, A.T. Rogers, N.D. Kon, and J.W. Hammon Intraoperative insulin therapy does not reduce the need for inotropic or antiarrhythmic therapy after cardiopulmonary bypass J Cardiothorac Vasc Anesth 16 2002 405 412
S.L. Greene, I. Gawarammana, D.M. Wood, A.L. Jones, and P.I. Dargan Relative safety of hyperinsulinaemia/euglycaemia therapy in the management of calcium channel blocker overdose: a prospective observational study Intensive Care Med 33 2007 2019 2024
W. Haider, F. Coraim, I. Duma, F. Eckersberger, H. Kassal, and M. Semsroth Effect of insulin on cardiac output after open heart surgery Anaesthesist 30 1981 350 354 [author's transl.]
L.A. Brodin, G. Dahlgren, S. Ekestrom, G. Settergren, and G. Ohqvist Influence of glucose-insulin-potassium on left ventricular function during coronary artery bypass grafting Scand J Thorac Cardiovasc Surg 27 1993 27 34
C. Girard, P. Quentin, H. Bouvier, P. Blanc, O. Bastien, and J.J. Lehot Glucose and insulin supply before cardiopulmonary bypass in cardiac surgery: a double-blind study Ann Thorac Surg 54 1992 259 263
U.W. Kjellman, K. Bjork, A. Dahlin, R. Ekroth, K. Kirno, and G. Svensson Insulin(GIK) improves myocardial metabolism in patients during blood cardioplegia Scand Cardiovasc J 34 2000 321 330
M. Hiesmayr, W.J. Haider, G. Grubhofer, D. Heilinger, F.P. Keznickl, and P. Mares Effects of dobutamine versus insulin on cardiac performance, myocardial oxygen demand, and total body metabolism after coronary artery bypass grafting J Cardiothorac Vasc Anesth 9 1995 653 658
Z. Szabo, H. Arnqvist, E. Hakanson, L. Jorfeldt, and R. Svedjeholm Effects of high-dose glucose-insulin-potassium on myocardial metabolism after coronary surgery in patients with Type II diabetes Clin Sci (Lond) 101 2001 37 43
W. Haider, H. Benzer, F. Coraim, R. Khosropour, W. Mohl, and M. Muller Postoperative therapy by means of acute parenteral alimentation (APA) with high doses of insulin and glucose after open heart surgery Anaesthesist 30 1981 53 63 [author's transl]
T. Doenst, W. Bothe, and F. Beyersdorf Therapy with insulin in cardiac surgery: controversies and possible solutions Ann Thorac Surg 75 2003 S721 S728
H. Bohrer, F. Fleischer, and C. Krier Hyperkalemic cardiac arrest after cardiac surgery following high-dose glucose-insulin-potassium infusion for inotropic support Anesthesiology 69 1988 949 953
S. Svensson, E. Berglin, R. Ekroth, I. Milocco, F. Nilsson, and G. William-Olsson Haemodynamic effects of a single large dose of insulin in open heart surgery Cardiovasc Res 18 1984 697 701
R. Svedjeholm, S. Hallhagen, R. Ekroth, P.O. Joachimsson, and G. Ronquist Dopamine and high-dose insulin infusion (glucose-insulin-potassium) after a cardiac operation: effects on myocardial metabolism Ann Thorac Surg 51 1991 262 270
S. Svensson, R. Ekroth, F. Nilsson, J. Ponten, and G. William-Olsson Insulin as a vasodilating agent in the first hour after cardiopulmonary bypass Scand J Thorac Cardiovasc Surg 23 1989 139 143
L. Lindholm, A. Bengtsson, V. Hansdottir, A. Westerlind, and A. Jeppsson Insulin (GIK) improves central mixed and hepatic venous oxygenation in clinical cardiac surgery Scand Cardiovasc J 35 2001 347 352
R. Svedjeholm, I. Huljebrant, E. Hakanson, and I. Vanhanen Glutamate and high-dose glucose-insulin-potassium (GIK) in the treatment of severe cardiac failure after cardiac operations Ann Thorac Surg 59 1995 S23 S30
P.E. Lheureux, S. Zahir, M. Gris, A.S. Derrey, and A. Penaloza Bench-to-bedside review: hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers Crit Care 10 2006 212
J.S. Holger, K.M. Engebretsen, and J.J. Marini High dose insulin in toxic cardiogenic shock Clin Toxicol 47 2009 303 307
C. Page, L.P. Hacket, and G.K. Isbister The use of high-dose insulin-glucose euglycemia in beta-blocker overdose: a case report J Med Toxicol 5 2009 139 143
S.J. Stellpflug, C.R. Harris, K.M. Engebretsen, J.B. Cole, and J.S. Holger Intentional overdose with cardiac arrest treated with intravenous fat emulsion and high-dose insulin Clin Toxicol (Phila) 48 2010 227 229
A. Vanderschuren, and P. Hantson Hyperinsulinemic euglycemia therapy for stunned myocardium following subarachnoid hemorrhage J Neurosurg 110 2009 64 66
J.S. Holger, D.J. Dries, K.W. Barringer, B.J. Peake, T.J. Flottemesch, and J.J. Marini Cardiovascular and metabolic effects of high-dose insulin in a porcine septic shock model Acad Emerg Med 17 2010 429 435
A.V. Fields, B. Patterson, A.A. Karnik, and R.P. Shannon Glucagon-like peptide-1 and myocardial protection: more than glycemic control Clin Cardiol 32 2009 236 243
H. Tuunanen, E. Engblom, A. Naum, K. Nagren, M. Scheinin, and B. Hesse Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy Circulation 118 2008 1250 1258