Reference : Recent advances in the understanding of the role of nitric oxide in cardiovascular ho...
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
Recent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis.
Schulz, R. [> > > >]
Rassaf, T. [> > > >]
MASSION, Paul mailto [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs]
Kelm, M. [> > > >]
Balligand, J.-L. [> > > >]
Pharmacology and Therapeutics
Elsevier Science
Yes (verified by ORBi)
[en] Animals ; Atherosclerosis/etiology ; Cardiovascular System/metabolism ; Heart/physiology ; Homeostasis ; Humans ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/metabolism
[en] Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation. To date, 3 distinct NOS isoforms have been identified: neuronal NOS (NOS1), inducible NOS (NOS2), and endothelial NOS (NOS3). Biochemically, NOS consists of a flavin-containing reductase domain, a heme-containing oxygenase domain, and regulatory sites. NOS catalyse an overall 5-electron oxidation of one Nomega-atom of the guanidino group of L-arginine to form NO and L-citrulline. NO exerts a plethora of biological effects in the cardiovascular system. The basal formation of NO in mitochondria by a mitochondrial NOS seems to be one of the main regulators of cellular respiration, mitochondrial transmembrane potential, and transmembrane proton gradient. This review focuses on recent advances in the understanding of the role of enzyme and enzyme-independent NO formation, regulation of NO bioactivity, new aspects of NO on cardiac function and morphology, and the clinical impact and perspectives of these recent advances in our knowledge on NO-related pathways.

File(s) associated to this reference

Fulltext file(s):

Restricted access
PHARMACOL THER 2005 108 3 225-56.pdfPublisher postprint508.82 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.