Computational modelling of biomaterial surface interactions with blood platelets and osteoblastic cells for the prediction of contact osteogenesis.

Amor, N.; Geris, Liesbet; Vander Sloten, Jos; Van Oosterwyck, H.

doi:10.1016/j.actbio.2010.09.025

Article (Scientific journals)

Computational modelling of biomaterial surface interactions with blood platelets and osteoblastic cells for the prediction of contact osteogenesis.

Amor, N.; Geris, Liesbet; Vander Sloten, Jos et al.

2011 • In Acta Biomaterialia, 7 (2), p. 779-90

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/109801

DOI
10.1016/j.actbio.2010.09.025

PubMed
20883839

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Keywords :

Animals; Biocompatible Materials/pharmacology; Blood Platelets/cytology/drug effects; Bone Density/drug effects; Cell Communication/drug effects; Computer Simulation; Dogs; Extracellular Matrix/drug effects/metabolism; Humans; Intercellular Signaling Peptides and Proteins/metabolism; Models, Biological; Osteoblasts/cytology/drug effects; Osteogenesis/drug effects; Surface Properties/drug effects; Time Factors

Abstract :

[en] Surface microroughness can induce contact osteogenesis (bone formation initiated at the implant surface) around oral implants, which may result from different mechanisms, such as blood platelet-biomaterial interactions and/or interaction with (pre-)osteoblast cells. We have developed a computational model of implant endosseous healing that takes into account these interactions. We hypothesized that the initial attachment and growth factor release from activated platelets is crucial in achieving contact osteogenesis. In order to investigate this, a computational model was applied to an animal experiment [7] that looked at the effect of surface microroughness on endosseous healing. Surface-specific model parameters were implemented based on in vitro data (Lincks et al. Biomaterials 1998;19:2219-32). The predicted spatio-temporal patterns of bone formation correlated with the histological data. It was found that contact osteogenesis could not be predicted if only the osteogenic response of cells was up-regulated by surface microroughness. This could only be achieved if platelet-biomaterial interactions were sufficiently up-regulated as well. These results confirmed our hypothesis and demonstrate the added value of the computational model to study the importance of surface-mediated events for peri-implant endosseous healing.

Disciplines :

Engineering, computing & technology: Multidisciplinary, general & others

Author, co-author :

Amor, N.

Geris, Liesbet ; Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique

Vander Sloten, Jos

Van Oosterwyck, H.

Language :

English

Title :

Computational modelling of biomaterial surface interactions with blood platelets and osteoblastic cells for the prediction of contact osteogenesis.

Publication date :

2011

Journal title :

Acta Biomaterialia

ISSN :

1742-7061

eISSN :

1878-7568

Publisher :

Elsevier Science, Oxford, United Kingdom

Volume :

Issue :

Pages :

779-90

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 25 January 2012

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