[en] Surface microroughness can induce contact osteogenesis (bone formation initiated at the implant surface) around oral implants, which may result from different mechanisms, such as blood platelet-biomaterial interactions and/or interaction with (pre-)osteoblast cells. We have developed a computational model of implant endosseous healing that takes into account these interactions. We hypothesized that the initial attachment and growth factor release from activated platelets is crucial in achieving contact osteogenesis. In order to investigate this, a computational model was applied to an animal experiment [7] that looked at the effect of surface microroughness on endosseous healing. Surface-specific model parameters were implemented based on in vitro data (Lincks et al. Biomaterials 1998;19:2219-32). The predicted spatio-temporal patterns of bone formation correlated with the histological data. It was found that contact osteogenesis could not be predicted if only the osteogenic response of cells was up-regulated by surface microroughness. This could only be achieved if platelet-biomaterial interactions were sufficiently up-regulated as well. These results confirmed our hypothesis and demonstrate the added value of the computational model to study the importance of surface-mediated events for peri-implant endosseous healing.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Amor, N.
Geris, Liesbet ; Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique
Vander Sloten, Jos
Van Oosterwyck, H.
Language :
English
Title :
Computational modelling of biomaterial surface interactions with blood platelets and osteoblastic cells for the prediction of contact osteogenesis.
Publication date :
2011
Journal title :
Acta Biomaterialia
ISSN :
1742-7061
eISSN :
1878-7568
Publisher :
Elsevier Science, Oxford, United Kingdom
Volume :
7
Issue :
2
Pages :
779-90
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
B.D. Boyan, and Z. Schwartz Response of musculoskeletal cells to biomaterials J Am Acad Orthop Surg 14 2006 S157 S162
J.E. Davies, and M.M. Hosseini Histodynamics of endosseous wound healing J.E. Davies, Bone engineering 2000 Em Squared Inc. Toronto 1 14
D.L. Cochran, and D. Buser Bone response to sandblasted and acid-attacked titanium: experimental and clinical studies J.E. Davies, Bone engineering 2000 Em Squared Inc. Toronto 392 398
I. Abrahamsson, T. Berglundh, E. Linder, N.P. Lang, and J. Lindhe Early bone formation adjacent to rough and turned endosseous implant surfaces. An experimental study in the dog Clin Oral Impl Res 15 2004 381 392
K. Vandamme, I. Naert, L. Geris, J. Vander Sloten, R. Puers, and J. Duck The effect of micro-motion on the tissue response around immediately loaded roughened titanium implants in the rabbit Eur J Oral Sci 115 2007 21 29
J.M. Anderson The cellular cascades of wound healing J.E. Davies, Bone engineering 2000 Em Squared Inc. Toronto 81 93
C.H. Gemmell, and J.K. Park Initial blood interactions with endosseous implant materials J.E. Davies, Bone engineering 2000 Em Squared Inc. Toronto 108 117
L. Kikuchi, J.Y. Park, C. Victor, and J.E. Davies Platelet interactions with calcium-phosphate-coated surfaces Biomaterials 26 2005 5285 5295
J.Y. Martin, Z. Schwartz, T.W. Hummert, D.M. Schraub, J. Simpson, and J. Lankford Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63) J Biomed Mater Res 29 1995 389 401
K. Kieswetter, Z. Schwartz, T.W. Hummert, D.L. Cochran, J. Simpson, and D.D. Dean Surface roughness modulates the local production of growth factors and cytokines by osteoblast-like MG-63 cells J Biomed Mater Res 32 1996 55 63
Z. Schwartz, K. Kieswetter, D.D. Dean, and B.D. Boyan Underlying mechanisms at the bone-implant interface during regeneration J Periodont Res 32 1997 166 171
J. Lincks, B.D. Boyan, C.R. Blanchard, C.H. Lohmann, Y. Liu, and D.L. Cochran Responses of MG63 osteoblast-like cells to titanium and titanium alloy is dependent on surface roughness and composition Biomaterials 19 1998 2219 2232 (Pubitemid 28550378)
B.D. Boyan, V.L. Sylvia, Y. Liu, R. Sagun, D.L. Cochran, and C.H. Lohmann Surface roughness mediates its effects on osteoblasts via protein A and phospholipase A2 Biomaterials 20 1999 2305 2310
Z. Schwartz, C.H. Lohmann, J. Oefinger, L.F. Bonewald, D.D. Dean, and B.D. Boyan Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage Adv Dent Res 13 1999 38 48
C.H. Lohmann, L.F. Bonewald, M.A. Sisk, V.L. Sylvia, D.L. Cochran, and D.D. Dean Maturation state determines the response of osteogenic cells to surface roughness and 1,25-dihydroxyvitamin D3 J Bone Miner Res 15 2000 1169 1180
Z. Schwartz, C.H. Lohmann, M. Sisk, D.L. Cochran, V.L. Sylvia, and J. Simpson Local factor production by MG63 osteoblast-like cells in response to surface roughness and 1.25-(OH)2D3 is mediated via protein kinase C- and protein kinase A-dependent pathways Biomaterials 22 2001 731 741
O. Zinger, G. Zhao, Z. Schwartz, J. Simpson, M. Wieland, and D. Landolt Differential regulation of osteoblasts by substrate microstructural features Biomaterials 26 2005 1837 1847
T.P. Kunzler, T. Drobek, M. Schuler, and N.D. Spencer Systematic study of osteoblast and fibroblast response to roughness by means of surface-morphology gradients Biomaterials 28 2007 2175 2182 (Pubitemid 46216454)
H. Schweikl, R. Müller, C. Englert, K.A. Hiller, R. Kujat, and M. Nerlich Proliferation of osteoblasts and fibroblasts on model surfaces of varying roughness and surface chemistry J Mater Sci Mater Med 18 2007 1895 1905
G. Zhao, A.L. Raines, M. Wieland, Z. Schwartz, and B.D. Boyan Requirement for both micron- and submicron scale structure for synergetic responses of osteoblasts to substrate surface energy and topography Biomaterials 28 2007 2821 2829
Z. Schwartz, R. Olivares-Navarrete, M. Wieland, D.L. Cochran, and B.D. Boyan Mechanisms regulating increased production of osteoprotegerin by osteoblasts cultured on microstructured titanium surfaces Biomaterials 30 2009 3390 3396
L. Geris, J. Vander Sloten, and H. Van Oosterwyck In silico biology of bone modelling and remodelling: Regeneration Philos Transact A Math Phys Eng Sci 367 2009 2031 2053
D. Ambard, and P. Swider A predictive mechano-biological model of the bone-implant healing Eur J Mech A Solids 2 2006 927 937
N. Amor, L. Geris, J. Vander Sloten, and H. Van Oosterwyck Modelling the early phases of bone regeneration around an endosseous oral implant Comput Methods Biomech Biomed Eng 4 2009 459 468
P. Moreo, J.M. Garcia-Aznar, and M. Doblaré Bone ingrowth on the surface of endosseous implants. Part 1: mathematical model J Theor Biol 260 2008 1 12
A. Bailn Plaza, and M.C.H. van der Meulen A mathematical framework to study the effects of growth factor influences on fracture healing J Theor Biol 212 2001 191 209
L. Sennerby, L.G. Persson, T. Berglundh, A. Wennerberg, and J. Lindhe Implant stability during initiation and resolution of experimental periimplantitis: an experimental study in the dog Clin Implant Dent Relat Res 7 2005 136 140 (Pubitemid 41551722)
T. Berglundh, I. Abrahamsson, N.P. Lang, and J. Lindhe De novo alveolar bone formation adjacent to endosseous implants. A model study in the dog Clin Oral Implant Res 14 2003 251 262
M. Lind, E.F. Eriksen, and C. Bünger Bone morphogenic protein-2 but not bone morphogenic protein-4 and -6 stimulates chemotactic migration of human osteoblasts, human marrow osteoblasts and U2-OS cells Bone 18 1996 53 57
J. Fiedler, G. Roderer, K.P. Gunther, and R.E. Brenner BMP-2, BMP-4, and PDGF-bb stimulate chemotactic migration of primary human mesenchymal progenitor cells J Cell Biochem 87 2002 305 312
J. Fiedler, N. Etzel, and R.E. Brenner To go or not to go: migration of human mesenchymal progenitor cells stimulated by isoforms of PDGF J Cell Biochem 93 2004 990 998
J. Fiedler, F. Leucht, J. Waltenberger, C. Dehio, and R.E. Brenner VEGF-A and PIGF-1 stimulate chemotactic migration of human mesenchymal progenitor cells Biochem Biophys Res Commun 334 2005 561 568
J. Fiedler, C. Brill, W.F. Blum, and R.E. Brenner IGF-I and IGF-II stimulate directed cell migration of bone-marrow-derived human mesenchymal progenitor cells Biochem Biophys Res Commun 345 2006 1177 1183
S. Jones, and A. Boyle The migration of osteoblasts Cell Tissue Res 184 1977 179 193
J.E. Davies In vitro modeling of bone/implant interface Anat Rec 245 1996 426 445
A. Gerisch, and M.A.J. Chaplain Robust numerical methods for taxis-diffusion-reaction systems: applications to biomedical problems Math Comput Model 43 2005 49 75
J.Y. Park, C.H. Gemmell, and J.E. Davies Platelet interactions with titanium: modulation of platelet activity by surface topography Biomaterials 22 2001 2671 2682
M.E. Joyce, A.B. Roberts, M.B. Sporn, and M.E. Bolander Transforming growth factor-β and the initiation of chondrogenesis and osteogenesis in the rat femur J Cell Biol 110 1990 2195 2207
H. Gruler, and B.D. Bültmann Analysis of cell movement Blood Cells 10 1984 61 77
L. Olsen, J.A. Sherratt, P.K. Maini, and F. Arnold A mathematical model for the capillary endothelial cell-extracellular matrix interactions in wound-healing angiogenesis IMA J Math Appl Med Biol 14 1997 261 281
A. Vander, J. Sherman, and D. Luciano Human physiology: the mechanics of body function 1998 WCB McGraw-Hill Boston, MA
R.J. Coffey, W.E. Russel, and J.A. Barbard Phamacokinetics of TGF beta with emphasis on effects in liver and gut Ann NY Acad Sci 593 1990 285 291
J.R. Dasch, D.R. Pace, W. Waegell, D. Inenaga, and L. Ellingsworth Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification J Immunol 142 1989 1536 1541
E.R. Edelman, M.A. Nugent, and M.J. Karnovsky Perivascular and intravenous administration of basic fibroblast growth factor: vascular and solid organ deposition Proc Natl Acad Sci USA 90 1993 1513 1517
J. Duyck, K. Vandamme, L. Geris, H. Van Oosterwyck, M. De Cooman, and Sloten Vander The influence of micro-motion on the tissue differentiation around immediately loaded cylindrical turned titanium implants Arch Oral Biol 51 2006 1 9
P. Leucht, J.B. Kim, R. Wazen, J.A. Currey, A. Nanci, and J.B. Brunski Effect of mechanical stimuli on skeletal regeneration around implants Bone 40 2007 919 930
K. Vandamme, I. Naert, J. Vander Sloten, R. Puers, and J. Duyck Effect of implant surface roughness and loading on peri-implant bone formation J Periodontol 79 2008 150 157
A. Bailon-Plaza, and M.C. Van der Meulen Beneficial effects of moderate, early loading and adverse effects of delayed or excessive loading on bone healing J Biomech 36 2003 1069 1077
Geris L, Vander Sloten J, Van Oosterwyck H. Connecting biology and mechanics in fracture healing: an integrated mathematical modeling framework for the study of nonunions. Biomech Model Mechanobiol 2010. doi:10.1007/s10237-010- 0208-8.
R.B. Dickinson, and R.T. Tranquillo A stochastic model for adhesion mediated cell random motility and haptokinesis J Math Biol 31 1993 563 600
L. Geris, A. Gerisch, C. Maes, G. Carmeliet, R. Weiner, and J. Vander Sloten Mathematical modeling of fracture healing in mice: comparison between experimental data and numerical simulation results Med Biol Eng Comput 44 2006 280 289
L. Geris, A. Gerisch, J. Vander Sloten, R. Weiner, and H. Van Oosterwyck Angiogenesis in bone fracture healing: a bioregulatory model J Theor Biol 251 2008 137 158
C.M. Stanford Surface modification of biomedical and dental implants and the processes of inflammation, wound healing and bone formation Int J Mol Sci 11 2010 354 369
W. Hundsdorfer, and J.G. Verwer Numerical solution of time dependent advection- diffusion-reaction equations Springer Series in Computational Mathematics vol. 33 2003 Springer Berlin
R. Weiner, B.A. Schmitt, and H. Podhaisky ROWMAP - a ROW-code with Krylov techniques for large stiff ODEs Appl Numer Math 25 1997 303 319