Mechanical loading affects angiogenesis and osteogenesis in an in vivo bone chamber: a modeling study.

Animals; Biomechanics/physiology; Bone and Bones/physiology; Computer Simulation; Implants, Experimental; Materials Testing; Models, Biological; Neovascularization, Physiologic; Osteogenesis/physiology; Rabbits; Weight-Bearing/physiology; Wound Healing

Abstract :

[en] Despite a myriad of studies confirming the interaction between biology and mechanics, the exact nature of the main mechanical stimuli and their influence on the bone regeneration processes are still unclear. The hypothesis of this study was that the outcome of peri-implant healing under different implant loading regimens can be explained by the influence of fluid flow on the combination of angiogenesis and osteogenesis through its influence on cell proliferation and differentiation. To investigate this hypothesis a mathematical model of bone regeneration was applied to simulate the peri-implant healing in an in vivo repeated sampling bone chamber for different axial micromechanical implant loading regimes. When mechanical loading was modeled to influence both osteogenic and angiogenic processes, a good agreement was observed between simulations and experiments concerning the amount of bone in the bone chamber, its radial and longitudinal distribution, and the bone-implant contact for different implant displacement magnitudes.

Disciplines :

Engineering, computing & technology: Multidisciplinary, general & others

Author, co-author :

Geris, Liesbet ; Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique

Vandamme, Katleen

Naert, Ignace

Vander Sloten, Jos

Van Oosterwyck, Hans

Duyck, Joke

Language :

English

Title :

Mechanical loading affects angiogenesis and osteogenesis in an in vivo bone chamber: a modeling study.

Publication date :

2010

Journal title :

Tissue Engineering. Part A

ISSN :

1937-3341

eISSN :

1937-335X

Publisher :

Mary Ann Liebert, United States - New York

Volume :

Issue :

Pages :

3353-3361

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 January 2012

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