Article (Scientific journals)
Controlled release of drugs from multi-component biomaterials
Zalfen, Alina; Nizet, D.; Jérôme, Christine et al.
2008In Acta Biomaterialia, 4 (6), p. 1788-1796
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Keywords :
biomaterial; nanomedicine; implant
Abstract :
[en] In order to control their release, drugs are encapsulated into systems which are expected to provide a certain site with a predetermined amount of drug over a well-defined period of time. Here we report on a multi-component drug delivery biomaterial that consists of a hydrogel matrix in which drug-loaded biodegradable microcarriers are dispersed, and whose potential applications could be found in the design of implantable devices with long-term activity, as required by contraceptive and hormone replacement treatments. The release profile of the drug can actually be tuned by the complex interplay of several release mechanisms, including the permeability and eventually the degradation rate of the microcarriers and the diffusion through the hydrogel. The hydrogel consisted of 2-hydroxyethyl methacrylate cross-linked by ethylene glycol dimethacrylate. The microcarriers were biodegradable poly-ε-caprolactone (PCL) microspheres in which active molecules, such as levonorgestrel (LNG), were encapsulated. The hydrogels were characterized by water swelling, thermal properties, LNG diffusion through drug-free and drug-depleted hydrogel membranes and LNG release from devices with drug dispersed in the hydrogel. The PCL microspheres were observed by scanning electron microscopy; their size distribution, LNG loading and release were also investigated. The hydrogel-microsphere assemblies were characterized in terms of the distribution of the microspheres within the hydrogel, water swelling and the release of the encapsulated molecules. The developed device, due to its composite structure, has the ability to combine several release mechanisms, leading to drug release obeying zero-order kinetics for most of the time.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Pharmacy, pharmacology & toxicology
Chemistry
Materials science & engineering
Author, co-author :
Zalfen, Alina ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Nizet, D.;  Université de Liège - ULiège > Institut de Pharmacie > Laboratory of Pharmaceutical Technology
Jérôme, Christine  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Robert ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
frankenne, F.;  Université de Liège - ULiège > Laboratoire de Biologie des Tumeurs et du Développement
Foidart, Jean-Michel ;  Université de Liège - ULiège > Laboratoire de Biologie des Tumeurs et du Développement
Maquet, Véronique;  Kitozyme, Herstal, Belgium
Lecomte, Frédéric  ;  Université de Liège - ULiège > Laboratory of Analytical Chemistry
Hubert, Philippe  ;  Université de Liège - ULiège > Laboratory of Analytical Chemistry
Evrard, Brigitte  ;  Université de Liège - ULiège > Institut de Pharmacie > Laboratory of Pharmaceutical Technology
Language :
English
Title :
Controlled release of drugs from multi-component biomaterials
Publication date :
November 2008
Journal title :
Acta Biomaterialia
ISSN :
1742-7061
eISSN :
1878-7568
Publisher :
Elsevier Science, Oxford, United Kingdom
Volume :
4
Issue :
6
Pages :
1788-1796
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
The Walloon Region in the framework of the IMPUT project through the DGTRE
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
Commentary :
The authors acknowledge Acta Biomaterialia (Elsevier) for allowing them to archive this paper.
Available on ORBi :
since 11 April 2009

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