Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging.

Adult; Aged; Aging/physiology; Alzheimer Disease/physiopathology; Brain/physiology/physiopathology; Electroencephalography; Female; Humans; Male; Transcranial Magnetic Stimulation

Abstract :

[en] The frontal cortex undergoes macrostructural and microstructural changes across the lifespan. These changes can be entirely physiological, such as the ones occurring in elderly individuals who are cognitively intact, or pathological, such as the ones occurring in patients with Alzheimer's disease. Here, we use simultaneous electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to study how the excitability of the frontal cortex changes during healthy and pathological aging. Hence, we compared the TMS-evoked EEG potentials collected in healthy elderly individuals with the ones collected in healthy young individuals, and in patients with Alzheimer's disease. We have shown that the EEG response to TMS of the left superior frontal cortex is not affected by physiological aging but is markedly altered by cognitive impairment.

Disciplines :

Neurology

Author, co-author :

Casarotto, Silvia

Maatta, Sara

Herukka, Sanna-Kaisa

Pigorini, Andrea

Napolitani, Martino

Gosseries, Olivia ; Université de Liège - ULiège > Coma Science Group, Centre de Recherches du Cyclotron ULiège & service de neurologie CHU de Liège

Niskanen, Eini

Kononen, Mervi

Mervaala, Esa

Rosanova, Mario

Soininen, Hilkka

Massimini, Marcello

Language :

English

Title :

Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging.

Publication date :

2011

Journal title :

Neuroreport

ISSN :

0959-4965

eISSN :

1473-558X

Publisher :

Lippincott Williams & Wilkins, London, United Kingdom

Volume :

Issue :

Pages :

592-7

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 21 January 2012

Statistics

Number of views

257 (7 by ULiège)

Number of downloads

591 (4 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

Bibliography

Ilmoniemi RJ, Virtanen J, Ruohonen J, Karhu J, Aronen HJ, Näätänen R, et al. Neuronal responses to magnetic stimulation reveal cortical reactivity and connectivity. Neuroreport 1997; 8:3537-3540. (Pubitemid 27497479)
Komssi S, Kähkönen S. The novelty value of the combined use of electroencephalography and transcranial magnetic stimulation for neuroscience research. Brain Res Rev 2006; 52:183-192. (Pubitemid 44051536)
Virtanen J, Ruohonen J, Näätänen R, Ilmoniemi RJ. Instrumentation for the measurement of electric brain responses to transcranial magnetic stimulation. Med Biol Eng Comput 1999; 37:322-326. (Pubitemid 29265294)
Ilmoniemi RJ, Kičić D. Methodology for combined TMS and EEG. Brain Topogr 2010; 22:233-248.
Massimini M, Ferrarelli F, Huber R, Esser SK, Singh H, Tononi G. Breakdown of cortical effective connectivity during sleep. Science 2005; 309:2228-2232. (Pubitemid 41396075)
Ferrarelli F, Massimini M, Peterson MJ, Riedner BA, Lazar M, Murphy MJ, et al. Reduced evoked gamma oscillations in the frontal cortex in schizophrenia patients: A TMS/EEG study. Am J Psychiatry 2008; 165:996-1005.
Thut G, Pascual LA. A review of combined TMS-EEG studies to characterize lasting effects of repetitive TMS and assess their usefulness in cognitive and clinical neuroscience. Brain Topogr 2010; 22:219-232.
Ferreri F, Pasqualetti P, Maatta S, Ponzo D, Ferrarelli F, Tononi G, et al. Human brain connectivity during single and paired pulse transcranial magnetic stimulation. Neuroimage 2011; 54:90-102.
Rosanova M, Casali A, Bellina V, Resta F, Mariotti M, Massimini M. Natural frequencies of human corticothalamic circuits. J Neurosci 2009; 29:7679-7685.
Kähkönen S, Wilenius J, Komssi S, Ilmoniemi RJ. Distinct differences in cortical reactivity of motor and prefrontal cortices to magnetic stimulation. Clin Neurophysiol 2004; 115:583-588. (Pubitemid 38230985)
Lioumis P, Kičić D, Savolainen P, MäkeläJP, Kähkönen S. Reproducibility of TMS-evoked EEG responses. Hum Brain Mapp 2009; 30: 1387-1396.
Casarotto S, Romero Lauro LJ, Bellina V, Casali AG, Rosanova M, Pigorini A, et al. EEG responses to TMS are sensitive to changes in the perturbation parameters and repeatable over time. PLoS One 2010; 5:e10281.
Lemaitre H, Goldman AL, Sambataro F, Verchinski BA, Meyer-Lindenberg A, Weinberger DR, et al. Normal age-related brain morphometric changes: Nonuniformity across cortical thickness, surface area and gray matter voluměNeurobiol Aging 2011 (in press).
Terao Y, Ugawa Y. Basic mechanisms of TMS. J Clin Neurophysiol 2002; 19:322-343. (Pubitemid 35304367)
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34:939-944. (Pubitemid 14076461)
Casali AG, Casarotto S, Rosanova M, Mariotti M, Massimini M. General indices to characterize the electrical response of the cerebral cortex to TMS. Neuroimage 2010; 49:1459-1468.
Ruohonen J, Ilmoniemi RJ. Modeling of the stimulating field generation in TMS. Electroencephalogr Clin Neurophysiol Suppl 1999; 51:30-40.
Rossini PM, Barker AT, Berardelli A, Caramia MD, Caruso G, Cracco RQ, et al. Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: Basic principles and procedures for routine clinical application: Report of an IFCN committee. Electroencephalogr Clin Neurophysiol 1994; 91:79-92. (Pubitemid 24246462)
Rossini PM, Rossi S, Babiloni C, Polich J. Clinical neurophysiology of aging brain: From normal aging to neurodegeneration. Prog Neurobiol 2007; 83:375-400. (Pubitemid 350123566)
Julkunen P, Jauhiainen AM, Westeré n-Punnonen S, Pirinen E, Soininen H, Könönen M, et al. Navigated TMS combined with EEG in mild cognitive impairment and Alzheimer's disease: A pilot study. J Neurosci Methods 2008; 172:270-276.
Ferreri F, Pauri F, Pasqualetti P, Fini R, Dal Forno G, Rossini PM. Motor cortex excitability in Alzheimer's disease: A transcranial magnetic stimulation study. Ann Neurol 2003; 53:102-108. (Pubitemid 36083834)
Alagona G, Bella R, Ferri R, Carnemolla A, Pappalardo A, Costanzo E, et al. Transcranial magnetic stimulation in Alzheimer disease: Motor cortex excitability and cognitive severity. Neurosci Lett 2001; 314:57-60. (Pubitemid 33043804)
Di Lazzaro V, Oliviero A, Tonali PA, Marra C, Daniele A, Profice P, et al. Noninvasive in vivo assessment of cholinergic cortical circuits in AD using transcranial magnetic stimulation. Neurology 2002; 59:392-397. (Pubitemid 34857932)
Clark S, Tremblay F, Ste-Marie D. Differential modulation of corticospinal excitability during observation, mental imagery and imitation of hand actions. Neuropsychologia 2004; 42:105-112. (Pubitemid 37522012)
Kischka U, Mandir AS, Ghika J, Growdon JH. Electrophysiologic detection of extrapyramidal motor signs in Alzheimer's disease. Neurology 1993; 43:500-505. (Pubitemid 23088481)