Acido-basic properties of lipophilic substances: A surface potential approach

[en] A general procedure allowing the acido-basic properties of lipophilic compounds to be defined is described. Drugs are spread at the air-water interface and the surface potential is recorded at different pH values of the aqueous subphase. Comparison of this experimental parameter and the Gouy-Chapman theory prediction allows the calculation of the acid (or basic) dissociation constants and the surface charge density.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Caspers, J.

Goormaghtigh, E.

Ferreira, J.

Brasseur, Robert ; Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biophysique moléc. numér.

Vandenbranden, M.

Ruysschaert, J. M.

Language :

English

Title :

Acido-basic properties of lipophilic substances: A surface potential approach

Publication date :

February 1983

Journal title :

Journal of Colloid and Interface Science

ISSN :

0021-9797

eISSN :

1095-7103

Publisher :

Academic Press, Orlando, United States - Florida

Volume :

Issue :

Pages :

546-551

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 20 January 2012

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