Article (Scientific journals)
Effect of platelet-activating factor on bovine pulmonary function
Van de Weerdt, ML; Desmecht, Daniel; Lekeux, Pierre
1997In Veterinary Record, 141 (7), p. 168-172
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Keywords :
PAF; lung; Bos taurus
Abstract :
[en] The objectives of this study were to determine whether the infusion of platelet-activating factor would modify bovine pulmonary function, heart rate and platelet count and whether any such modifications could be antagonised by the prior intravenous injection of a specific antagonist (WEB 2086). In saline-pretreated calves, the respiratory rate, total lung resistance (RL) and maximal changes in transpulmonary pressure (delta Ptp) were significantly increased whereas lung dynamic compliance (CLdyn), tidal volume (VT), platelet count and heart rate were significantly decreased. The changes in RL, CLdyn, VT and delta Ptp were abolished by pretreatment with WEB 2086, whereas respiratory rate remained significantly increased to 125 per cent of the baseline value, but less than in the saline-pretreated calves in which it was 250 per cent of the baseline value.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Van de Weerdt, ML
Desmecht, Daniel ;  Université de Liège - ULiège > Département de morphologie et pathologie > Pathologie spéciale et autopsies
Lekeux, Pierre ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
Language :
English
Title :
Effect of platelet-activating factor on bovine pulmonary function
Publication date :
August 1997
Journal title :
Veterinary Record
ISSN :
0042-4900
eISSN :
2042-7670
Publisher :
British Veterinary Medicine, London, United Kingdom
Volume :
141
Issue :
7
Pages :
168-172
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 January 2012

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