Anti-Bacterial Agents; Calcimycin; Calcium; Chemical Phenomena; Chemistry; Gliclazide; Glipizide; Magnetic Resonance Spectroscopy; Molecular Conformation; Sulfonylurea Compounds; Tolbutamide
Abstract :
[en] Hypoglycemic sulfonylureas (e.g., gliclazide) are able to transport calcium across hydrophobic domains. Gliclazide and the ionophore A23187 act synergistically upon calcium transport. One calcium atom is complexed by either two molecules of sulfonylureas (or A23187) or one molecule each of sulfonylurea and A23187; the existence of such hybrid complexes has been documented by nuclear magnetic resonance. Conformation analysis of the calcium-gliclazide complex suggests close apposition of the toluyl groups in the gliclazide molecules.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Deleers, M.
Brasseur, Robert ; Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biophysique moléc. numér.
Gelbcke, M.
Malaisse, W. J.
Language :
English
Title :
Homologous and hybrid calcium complexes of A23187 and hypoglycemic sulfonylureas: nuclear magnetic resonance and conformational analysis.
Publication date :
1982
Journal title :
Journal of Inorganic Biochemistry
ISSN :
0162-0134
eISSN :
1873-3344
Publisher :
Elsevier Science, New York, United States - New York
Deleers, Gelbcke, Malaisse (1981) Formation of hybrid complexes between Ca2+ and the ionophores bromolasalocid (Br-X537A) and A23187. Proceedings of the National Academy of Sciences 78:279.
