Article (Scientific journals)
Developmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice
Quoilin, Caroline; Didone, Vincent; Tirelli, Ezio et al.
2012In Psychopharmacology, 219, p. 1165-1177
Peer Reviewed verified by ORBi
 

Files


Full Text
Psychopharmacology_2012_ontogeny.pdf
Publisher postprint (374.76 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Ethanol; Adolescence; Locomotor activity; Behavioral sensitization; Mice
Abstract :
[en] Rationale: The maturing adolescent brain has been suggested to be more sensitive than the adult brain to ethanol-induced neuroadaptations. In animal studies, sensitization to the stimulant effects of ethanol is used to study the vulnerability to chronic ethanol-induced neurobehavioral alterations. Objectives: The aim of the present study was to systematically characterize age-dependent changes in the development and expression of the sensitization to the stimulant effects of a range of ethanol doses in female Swiss mice. Three ages were studied: 21-day-old mice (postweanlings), 35-day-old mice (adolescents), and 63-day-old mice (adults). Methods: Postweanling, adolescent, and adult mice were daily injected with saline or various ethanol doses (1.5 to 4 g/kg) for 7 days. They were then tested for acute and sensitized locomotor activity. Results: Postweanling and adolescent mice were more sensitive than adult mice to the acute stimulant effects of ethanol. In adult mice, daily injections of ethanol at doses between 2.5 and 4 g/kg led to significant sensitization. Higher ethanol doses (3.5 and 4 g/kg) were required to induce sensitization in postweanling and adolescent mice. However, younger mice showed ethanol sensitization of higher magnitude. Conclusions: Young mice develop very strong ethanol sensitization at doses that mimic binge drinking in humans. These results might explain why early ethanol drinking during adolescence is related to a higher prevalence of subsequent alcohol disorders.
Research center :
Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Quoilin, Caroline ;  Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Psychologie quantitative
Didone, Vincent ;  Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Psychologie quantitative
Tirelli, Ezio ;  Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Neuroscience comportementale et psychopharmacologie expér.
Quertemont, Etienne  ;  Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Psychologie quantitative
Language :
English
Title :
Developmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice
Publication date :
2012
Journal title :
Psychopharmacology
ISSN :
0033-3158
eISSN :
1432-2072
Publisher :
Springer Verlag, Berlin, Germany
Volume :
219
Pages :
1165-1177
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 17 January 2012

Statistics


Number of views
92 (24 by ULiège)
Number of downloads
4 (3 by ULiège)

Scopus citations®
 
18
Scopus citations®
without self-citations
12
OpenCitations
 
16

Bibliography


Similar publications



Contact ORBi