Article (Scientific journals)
IL28B polymorphism and the control of hepatitis C virus infection: ready for clinical use?
Orlent, Hans; Reynaert, Hendrik; Bourgeois, Stefan et al.
2011In Acta Gastro-Enterologica Belgica, 74 (2), p. 317-322
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Keywords :
Antiviral Agents/therapeutic use; DNA/genetics; Genotype; Hepacivirus/genetics; Hepatitis C/drug therapy/genetics/metabolism; Humans; Interleukins/genetics/metabolism; Polymorphism, Genetic
Abstract :
[en] Polymorphisms in the region of the interleukin-28B (IL28B) gene have recently been associated with spontaneous and treatment induced clearance of hepatitis C virus infection. The specific mechanisms of how IL28B polymorphisms affect HCV suppression remain unknown. It is a matter of ongoing debate how to incorporate the IL28B data into the current treatment algorithms with pegylated interferon-alpha and ribavirin. The eventual role of the IL28B genotype in new therapeutic regimes with direct antiviral agents needs to be explored in the ongoing and future clinical studies with these agents.
Disciplines :
Gastroenterology & hepatology
Genetics & genetic processes
Author, co-author :
Orlent, Hans
Reynaert, Hendrik
Bourgeois, Stefan
DIDEBERG, Vinciane ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
Adler, Michael
Colle, Isabelle
De Maeght, Stephane
Laleman, Wim
Michielsen, Peter
Moreno, Christophe
Mulkay, Jean-Pierre
Starkel, Peter
DELWAIDE, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
More authors (3 more) Less
Language :
English
Title :
IL28B polymorphism and the control of hepatitis C virus infection: ready for clinical use?
Publication date :
2011
Journal title :
Acta Gastro-Enterologica Belgica
ISSN :
0001-5644
eISSN :
1784-3227
Publisher :
Acta Medica Belgica, Bruxelles, Belgium
Volume :
74
Issue :
2
Pages :
317-322
Peer reviewed :
Peer Reviewed verified by ORBi
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