[en] The fund of knowledge regarding the versatility of presentation of MM metastases is still quite incomplete. The recent literature pertaining to the current understanding of the mechanisms underlying two special features of MM metastasis is reviewed. On the one hand, a long disease-free interval (MM dormancy) may occur before the surge of overt metastases. On the other hand, the so-called MM smouldering phenomenon refers to the condition where regional metastases wax and wane for long periods of time on restricted skin regions. It is important to emphasize that local micrometastases often predict sentinel lymph node involvement but may not reflect progression of the primary MM to full-blown visceral metastatic competence. It is likely that a combination of factors impacts the versatile MM metastasic progression. Among the main factors, one has to mention the phenotypic heterogeneity and variability in the phenotype of MM cells, the presence of MM stem cells and MM cells engaged in an amplification proliferation pool, as well as the host immune response, and possibly the induction of a particular stromal structure and vascularity.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
PIERARD, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Clark W. H., Tumour progression and the nature of cancer. British Journal of Cancer 1991 64 4 631 644 2-s2.0-0025909122
Elder D. E., Van Belle P., Elenitsas R., Halpern A., Guerry D., Neoplastic progression and prognosis in melanoma. Seminars in Cutaneous Medicine and Surgery 1996 15 4 336 348 2-s2.0-0030425747 (Pubitemid 27197972)
Quatresooz P., Piérard-Franchimont C., Paquet P., Piérard G. E., Angiogenic fast-growing melanomas and their micrometastases. European Journal of Dermatology 2010 20 3 302 307 2-s2.0-77952872508 10.1684/ejd.2010. 0929
Attis M. G., Vollmer R. T., Mitotic rate in melanoma: a reexamination. American Journal of Clinical Pathology 2007 127 3 380 384 2-s2.0-34247881910 10.1309/LB7RTC61B7LC6HJ6 (Pubitemid 46806331)
Balch C. M., Gershenwald J. E., Soong S. J., Thompson J. F., Atkins M. B., Byrd D. R., Buzaid A. C., Cochran A. J., Coit D. G., Ding S., Eggermont A. M., Flaherty K. T., Gimotty P. A., Kirkwood J. M., McMasters K. M., Mihm M. C., Morton D. L., Ross M. I., Sober A. J., Sondak V. K., Final version of 2009 AJCC melanoma staging and classification. Journal of Clinical Oncology 2009 27 36 6199 6206 2-s2.0-74949143594 10.1200/JCO.2009.23.4799
Piérard G. E., Piérard-Franchimont C., Henry C., Lapière M., The proliferative activity of cells of malignant melanomas. The American Journal of Dermatopathology 1984 6 1 S317 S323 2-s2.0-0021747706
Böni R., Doguoglu A., Burg G., Mûller B., Dummer R., MIB-1 immunoreactivity correlates with metastatic dissemination in primary thick cutaneous melanoma. Journal of the American Academy of Dermatology 1996 35 3 416 468 2-s2.0-0029775064
Frahm S. O., Schubert C., Parwaresch R., Rudolph P., High proliferative activity may predict early metastasis of thin melanomas. Human Pathology 2001 32 12 1376 1381 2-s2.0-0035677699 10.1053/hupa.2001.29658 (Pubitemid 34038673)
Plaza J. A., Suster D., Perez-Montiel D., Expression of immunohistochemical markers in primary and metastatic malignant melanoma: a comparative study in 70 patients using a tissue microarray technique. Applied Immunohistochemistry and Molecular Morphology 2007 15 4 421 425 2-s2.0-37349081263 10.1097/PAI.0b013e318032ea5d (Pubitemid 350307848)
Quatresooz P., Piérard G. E., Piérard-Franchimont C., Mosan Study Grop of Pigmented Tumors, Molecular pathways supporting the proliferation staging of malignant melanoma. International Journal of Molecular Medicine 2009 24 3 295 301 10.3892/ijmm-00000232
Quatresooz P., Piérard G. E., Malignant melanoma: from cell kinetics to micrometastases. American Journal of Clinical Dermatology 2011 12 2 77 86 10.2165/11318380-000000000-00000
Quatresooz P., Arrese J. E., Piérard-Franchimont C., Piérard G. E., Immunohistochemical aid at risk stratification of melanocytic neoplasms. International Journal of Oncology 2004 24 1 211 216 2-s2.0-3843107068
Holmgren L., O'Reilly M. S., Folkman J., Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Medicine 1995 1 2 149 153 2-s2.0-0028951043
Piérard G. E., Piérard-Franchimont C., Stochastic relationship between the growth fraction and vascularity of thin malignant melanomas. European Journal of Cancer 1997 33 11 1888 1892 2-s2.0-0344301855 10.1016/S0959-8049(97)00231-1 (Pubitemid 28129222)
Piérard-Franchimont C., Henry F., Heymans O., Piérard G. E., Vascular retardation in dormant growth-stunted malignant melanomas. International Journal of Molecular Medicine 1999 4 4 403 406 2-s2.0-0033208648
Mikesh L. M., Kumar M., Erdag G., Hogan K. T., Molhoek K. R., Mayo M. W., Slingluff C. L., Evaluation of molecular markers of mesenchymal phenotype in melanoma. Melanoma Research 2010 20 6 485 495 2-s2.0-78349312817 10.1097/CMR.0b013e32833fafb4
Quatresooz P., Reginster M. -A., Piérard G. E., The "Malignant melanoma microecosystem": immunohistopathological insights into the stromal cell phenotype: a review. Experimental and Therapeutic Medicine 2011 2 3 379 384 10.3892/etm.2011.221
Fang D., Nguyen T. K., Leishear K., Finko R., Kulp A. N., Hotz S., Van Belle P. A., Xu X., Elder D. E., Herlyn M., A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Research 2005 65 20 9328 9337 2-s2.0-27144557960 10.1158/0008-5472.CAN-05-1343 (Pubitemid 41508000)
Grichnik J. M., Burch J. A., Schulteis R. D., Shan S., Liu J., Darrow T. L., Vervaert C. E., Seigler H. F., Melanoma, a tumor based on a mutant stem cell? Journal of Investigative Dermatology 2006 126 1 142 153 2-s2.0-33644787015 10.1038/sj.jid.5700017 (Pubitemid 43336106)
Klein W. M., Wu B. P., Zhao S., Wu H., Klein-Szanto A. J. P., Tahan S. R., Increased expression of stem cell markers in malignant melanoma. Modern Pathology 2007 20 1 102 107 2-s2.0-33845702260 10.1038/modpathol.3800720 (Pubitemid 44967955)
Monzani E., Facchetti F., Galmozzi E., Corsini E., Benetti A., Cavazzin C., Gritti A., Piccinini A., Porro D., Santinami M., Invernici G., Parati E., Alessandri G., La Porta C. A. M., Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential. European Journal of Cancer 2007 43 5 935 946 2-s2.0-33847639310 10.1016/j.ejca.2007.01.017 (Pubitemid 46366698)
Piérard G. E., Quatresooz P., Rorive A., Piérard- Franchimont C., Mosan Study Group of Pigmented Tumors, Malignant melanoma: conceptual and therapeutic innovations based on translational research. Revue Médicale de Liège 2008 63 10 579 584
Henry C., Lapière M., Franchimont C., Piérard G. E., Lapière C. M., Ackerman A. B., Immunotherapy by dinitrochlorobenzene of melanomas of the skin: I- methods, clinical effects and survival rates. Pathology of Malignant Melanoma 1981 New York, NY, USA Pub Masson 367 371
Wang E., Voiculescu S. S., Le Poole I. C., El-Gamil M., Li X., Sabatino M., Robbins P. F., Nickoloff B. J., Marincola F. M., Clonal persistence and evolution during a decade of recurrent melanoma. Journal of Investigative Dermatology 2006 126 6 1372 1377 2-s2.0-33745517244 10.1038/sj.jid.5700193 (Pubitemid 43997921)
Strauss D. C., Thomas J. M., Transmission of donor melanoma by organ transplantation. The Lancet Oncology 2010 11 8 790 796 2-s2.0-77955268790 10.1016/S1470-2045(10)70024-3
Bodenham D. C., A study of 650 observed malignant melanomas in the South-West region. Annals of the Royal College of Surgeons of England 1968 43 4 218 239 2-s2.0-0014337912
Harrist T. J., Rigel D. S., Day C. L., Microscopic satellites are more highly associated with regional lymph node metastases than is primary melanoma thickness. Cancer 1984 53 10 2183 2187 (Pubitemid 14101792)
Leon P., Daly J. M., Synnestvedt M., Schultz D. J., Elder D. E., Clark W. H., The prognostic implications of microscopic satellites in patients with clinical stage I melanoma. Archives of Surgery 1991 126 12 1461 1468 2-s2.0-0026318663
Claessens N., Piérard G. E., Piérard-Franchimont C., Arrese J. E., Quatresooz P., Immunohistochemical detection of incipient melanoma micrometastases: relationship with sentinel lymph node involvement. Melanoma Research 2005 15 2 107 110 2-s2.0-18344369398 10.1097/00008390-200504000-00004 (Pubitemid 40637988)
Shaikh L., Sagebiel R. W., Ferreira C. M. M., Nosrati M., Miller J. R., Kashani-Sabet M., The role of microsatellites as a prognostic factor in primary malignant melanoma. Archives of Dermatology 2005 141 6 739 742 2-s2.0-21844432408 10.1001/archderm.141.6.739 (Pubitemid 41001074)
Piérard G. E., Henry C., Franchimont C., Lapière M., Ackerman A. B., Lapière C. M., Ackerman A. B., Immunotherapy by dinitrochlorobenzene of melanomas of the skin: II. Histology of the cytotoxic effect. Pathology of Malignant Melanoma 1981 New York, NY, USA Pub Masson 373 385
Moreno A., Espanol I., Romagosa V., Angiotropic malignant melanoma: report of two cases. Journal of Cutaneous Pathology 1992 19 4 325 329 2-s2.0-0026788295
Shea C. R., Kline M. A., Lugo J., McNutt N. S., Angiotropic metastatic malignant melanoma. The American Journal of Dermatopathology 1995 17 1 58 62 2-s2.0-0028890406
Saluja A., Money N., Zivony D. I., Solomon A. R., Angiotropic malignant melanoma: a rare pattern of local metastases. Journal of the American Academy of Dermatology 2001 44 5 829 832 2-s2.0-0035032089 10.1067/mjd.2001.114579 (Pubitemid 32391172)
Barnhill R. L., Reinhold U., Tilgen W., The biology of melanoma micrometastases. Minimal Residual Disease in Melanoma: Biology, Detection and Clinical Relevance 2001 Berlin, Germany Springer 3 13
Siegel D. M., McClain S. A., Angiotropic malignant melanoma: more common than we think? Journal of the American Academy of Dermatology 2001 44 5 870 871 2-s2.0-0035035743 10.1067/mjd.2001.114578 (Pubitemid 32391181)
Barnhill R., Dy K., Lugassy C., Angiotropism in cutaneous melanoma: a prognostic factor strongly predicting risk for metastasis. Journal of Investigative Dermatology 2002 119 3 705 706 2-s2.0-0036381821 10.1046/j.1523-1747.2002.01871.x
Barnhill R. L., Lugassy C., Angiotropic malignant melanoma and extravascular migratory metastasis: description of 36 with emphasis on a new mechanism of tumour spread. Pathology 2004 36 5 485 490 2-s2.0-4644242490 10.1080/00313020412331282708 (Pubitemid 39273994)
Lugassy C., Barnhill R. L., Angiotropic melanoma and extravascular migratory metastasis: a review. Advances in Anatomic Pathology 2007 14 3 195 201 2-s2.0-34247497633 10.1097/PAP.0b013e31805048d9 (Pubitemid 46659190)
Mantovani A., Molecular pathways linking inflammation and cancer. Current Molecular Medicine 2010 10 4 369 373 2-s2.0-77953485565 10.2174/ 156652410791316968
Sleeman J. P., Nazarenko I., Thiele W., Do all roads lead to Rome? Routes to metastasis development. International Journal of Cancer 2011 128 11 2511 2526 10.1002/ijc.26027
Klein C. A., Framework models of tumor dormancy from patient-derived observations. Current Opinion in Genetics and Development 2011 21 1 42 49 2-s2.0-78649733471 10.1016/j.gde.2010.10.011
Goss P. E., Chambers A. F., Does tumour dormancy offer a therapeutic target? Nature Reviews Cancer 2010 10 12 871 877 2-s2.0-78649467513 10.1038/nrc2933
Yang Z. J., Chee C. E., Huang S., Sinicrope F. A., Autophagy modulation for cancer therapy. Cancer Biology and Therapy 2011 11 2 169 176 10.4161/cbt.11.2.14663
Röcken M., Early tumor dissemination, but late metastasis: insights into tumor dormancy. Journal of Clinical Investigation 2010 120 6 1800 1803 2-s2.0-77953221417 10.1172/JCI43424
Eyles J., Puaux A. L., Wang X., Toh B., Prakash C., Hong M., Tan T. G., Zheng L., Ong L. C., Jin Y., Kato M., Prévost-Blondel A., Chow P., Yang H., Abastado J. P., Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma. Journal of Clinical Investigation 2010 120 6 2030 2039 2-s2.0-77953225810 10.1172/JCI42002