Article (Scientific journals)
Molecular dermatopathology in malignant melanoma.
REGINSTER, Marie-Annick; PIERARD-FRANCHIMONT, Claudine; PIERARD, Gérald et al.
2012In Dermatology Research and Practice, 2012 (684032), p. 1-6
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Abstract :
[en] At present, immunohistochemistry is taken for granted in the establishment of malignant melanoma (MM) diagnosis. In recent years, molecular diagnosis in dermatopathology has benefited from a vast array of advances in the fields of genomics and proteomics. Sensitive techniques are available for detecting specific DNA and RNA sequences by molecular hybridization. This paper intends to update methods of molecular cytogenetics available as diagnostic adjuncts in the field of MM. Cytogenetics has highlighted the pathogenesis of atypical melanocytic neoplasms with emphasis on the activation of the mitogen-activated protein kinase (MAPK) signalling pathway during the initiation step of the neoplasms. 20 to 40% of MM families have mutations in the tumour suppressor gene p16 or CDKN2A. In addition, somatic mutations in p16, p53, BRAF, and cKIT are present in MM. Genome-wide scan analyses on MM indicate positive associations for genes involved in melanocytic naevi, but MM is likely caused by a variety of common low-penetrance genes. Molecular dermatopathology is expanding, and its use in the assessment of melanocytic neoplasms appears to be promising in the fields of research and diagnosis. Molecular dermatopathology will probably make its way to an increased number of diagnostic laboratories. The expected benefit should improve the patient management. This evolution points to a need for evolution in the training requirements and role of dermatopathologists.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
REGINSTER, Marie-Annick ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
PIERARD-FRANCHIMONT, Claudine ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
PIERARD, Gérald ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
QUATRESOOZ, Pascale  ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Language :
English
Title :
Molecular dermatopathology in malignant melanoma.
Publication date :
2012
Journal title :
Dermatology Research and Practice
ISSN :
1687-6105
eISSN :
1687-6113
Publisher :
Hindawi Publishing Corporation, Egypt
Volume :
2012
Issue :
684032
Pages :
1-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 December 2011

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