Article (Scientific journals)
Neuroimaging insights into the pathophysiology of sleep disorders.
Desseilles, Martin; Dang Vu, Thien Thanh; Schabus, Manuel et al.
2008In Sleep, 31 (6), p. 777-94
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Keywords :
Brain/metabolism/physiopathology/radionuclide imaging; Comorbidity; Depression/diagnosis/epidemiology/psychology; Dopamine/metabolism; Electroencephalography; Humans; Iron/metabolism; Magnetic Resonance Imaging; Narcolepsy/diagnosis/epidemiology/physiopathology; Positron-Emission Tomography; REM Sleep Behavior Disorder/diagnosis/epidemiology/physiopathology; Receptors, Opioid/metabolism; Restless Legs Syndrome/diagnosis/epidemiology/physiopathology; Sleep Apnea, Obstructive/diagnosis/epidemiology/physiopathology; Sleep Disorders/diagnosis/epidemiology/physiopathology; Sleep Initiation and Maintenance Disorders/diagnosis/epidemiology/physiopathology; Tomography, Emission-Computed, Single-Photon
Abstract :
[en] Neuroimaging methods can be used to investigate whether sleep disorders are associated with specific changes in brain structure or regional activity. However, it is still unclear how these new data might improve our understanding of the pathophysiology underlying adult sleep disorders. Here we review functional brain imaging findings in major intrinsic sleep disorders (i.e., idiopathic insomnia, narcolepsy, and obstructive sleep apnea) and in abnormal motor behavior during sleep (i.e., periodic limb movement disorder and REM sleep behavior disorder). The studies reviewed include neuroanatomical assessments (voxel-based morphometry, magnetic resonance spectroscopy), metabolic/functional investigations (positron emission tomography, single photon emission computed tomography, functional magnetic resonance imaging), and ligand marker measurements. Based on the current state of the research, we suggest that brain imaging is a useful approach to assess the structural and functional correlates of sleep impairments as well as better understand the cerebral consequences of various therapeutic approaches. Modem neuroimaging techniques therefore provide a valuable tool to gain insight into possible pathophysiological mechanisms of sleep disorders in adult humans.
Disciplines :
Neurology
Author, co-author :
Desseilles, Martin ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Dang Vu, Thien Thanh ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Schabus, Manuel
Sterpenich, Virginie ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Maquet, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Schwartz, Sophie
Language :
English
Title :
Neuroimaging insights into the pathophysiology of sleep disorders.
Publication date :
2008
Journal title :
Sleep
ISSN :
0161-8105
eISSN :
1550-9109
Publisher :
Associated Professional Sleep Societies, Winchester, United States - Illinois
Volume :
31
Issue :
6
Pages :
777-94
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 06 December 2011

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