Article (Scientific journals)
Safety of long-term treatment of HAM/TSP patients with valproic acid
Olindo, Stéphane; Belrose, Gildas; Gillet, Nicolas et al.
2011In Blood, 118 (24), p. 6306-6309
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Abstract :
[en] HTLV-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a neurodegenerative disease of the central nervous system induced by Human T lymphotropic virus type 1 (HTLV-1). As a potential therapeutic approach, we previously suggested reducing the proviral load (PVL) by modulating lysine deacetylase activity using valproic acid (VPA) and exposing virus-positive cells to the host immune response. We conducted a single-center, two-year open-label trial, with 19 HAM/TSP volunteers treated with oral VPA. PVL, CD38/HLA-DR expression and CD8+ lysis efficiency were not significantly affected by VPA. Mean scores of HAM/TSP disability did not differ between baseline and final visit. Walking Time Test (WTT) increased significantly (>20%) in 3 patients and was in keeping with minor VPA side effects (drowsiness and tremor). WTT improved rapidly after VPA discontinuation. We conclude that long term treatment with VPA is safe in HAM/TSP.
Disciplines :
Oncology
Author, co-author :
Olindo, Stéphane
Belrose, Gildas
Gillet, Nicolas ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Rodriguez, Sabrina ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Boxus, Mathieu ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Verlaeten, Olivier
Asquith, Becca
Bangham, Charles
Signaté, Aïssatou
Smadja, Didier
Lezin, Agnès
Césaire, Raymond
Willems, Luc  ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
More authors (3 more) Less
Language :
English
Title :
Safety of long-term treatment of HAM/TSP patients with valproic acid
Publication date :
08 December 2011
Journal title :
Blood
ISSN :
0006-4971
eISSN :
1528-0020
Publisher :
American Society of Hematology, Washington, United States - District of Columbia
Volume :
118
Issue :
24
Pages :
6306-6309
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 30 November 2011

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