Regulation of major histocompatibility complex class I expression by NF-kB-related proteins in breast cancer cells

[en] Downregulation of MHC Class I antigens has been observed in many cancers and usually results from a decreased gene transcription. A reporter CAT gene dependent on the MHC Class I kB site or on a longer promoter is transactivated by NF-kB complexes contain- ing p65 or RelB. p100 as well as IkB-a are potent inhibitors of this transcription and p100 sequesters RelB and p65 complexes in the cytoplasm of breast cancer cells. However, although p100 is highly expressed in a number of breast cancer cell lines, MHC Class I antigen expression was observed on all the cell lines we analysed and could be further induced by stimulation with the cytokines IFN-g or TNF-a. Stable transfection of a unresponsive mutated IkB-a Ser 32-36 expression vector showed that TNF-a induced MHC Cl I expression in an NF-kB-dependent way while IFN-g did it independently of any NF-kB activation.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Dejardin, Emmanuel ; Université de Liège - ULiège > GIGA-R : Virologie - Immunologie

Deregowski, Valérie

GREIMERS, Roland ; Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique

Cai, Zhenzi

Chouaib, Salem

Merville, Marie-Paule ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

BOURS, Vincent ; Centre Hospitalier Universitaire de Liège - CHU > Génétique

Language :

English

Title :

Regulation of major histocompatibility complex class I expression by NF-kB-related proteins in breast cancer cells

Publication date :

1998

Journal title :

Oncogene

ISSN :

0950-9232

eISSN :

1476-5594

Publisher :

Nature Publishing Group, Basingstoke, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 15 November 2011

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