[en] In this review article on the origin of HIV, we start from a historical fact which involved physicians from Liege working in Belgian Congo: the vaccination against polio of hundreds of thousands of Congolese between 1957 and 1960. We explain the genesis of an alternative hypothesis postulating that this campaign was at the origin of HIV pandemy. We show that the hypothesis is unfounded in view of genetic and epidemiological evidence on the one hand and after thorough examination of the activity reports of the Laboratoire Medical de Stanleyville on the other. In the second part of the article, we analyse the importance of other factors which might have contributed to the emergence of the pandemy. Some of these are clearly iatrogenic such as the prophylactic injections of pentamidine against trypanosomiasis, others are of demographic and sociological nature. All of them have a direct link with colonisation.
Disciplines :
General & internal medicine
Author, co-author :
DOUPAGNE, Gaëlle ; Centre Hospitalier Universitaire de Liège - CHU > Service du personnel
Toukouki, A.
Moutschen, Michel ; Université de Liège - ULiège > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén.
Language :
French
Title :
Des interactions complexes entre les origines du VIH et sa pandemie, les activites coloniales en Afrique et la medecine coloniale Belge au Congo
Alternative titles :
[en] About the complex interactions between HIV origins and its pandemy, colonial activities in Africa and colonial medicine in Belgian Congo
Publication date :
2011
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Hooper E. - The river : a journey to the source of HIV and AIDS. Back Bay Books, Boston, MA, 2000.
Wolfe ND, Switzer WM, Carr JK, et al. - Naturally acquired simian retrovirus infections in central African hunters. Lancet, 2004, 363, 932-937. (Pubitemid 38388326)
Jaffe HW, Bregman DJ, Selik RM. - Acquired immune deficiency syndrome in the United States : the first 1,000 cases. J Infect Dis, 1983, 148, 339-345. (Pubitemid 13002478)
Sidley P. - Mbeki appoints team to look at cause of AIDS. BMJ, 2000, 320, 1291.
Curtis T. - A startling new theory attemps to answer the question "Was it an act of god or an act of man?". Rolling Stone Magazine, 1992, 54-59.
Courtois G, Flack A, Jervis GA, et al. - Preliminary report on mass vaccination of man with live attenuated poliomyelitis virus in the Belgian Congo and Ruanda-Urundi. Br Med J, 1958, 2, 187-190.
Plotkin SA, Lebrun A, Courtois G, et al.- Vaccination with the CHAT strain of type 1 attenuated poliomyelitis virus in Leopoldville, Congo. 3. Safety and efficacy during the first 21 months of study. Bull World Health Organ, 1961, 24, 785-792.
Plotkin SA, Lebrun A, Koprowski H. - Vaccination with the CHAT strain of type 1 attenuated poliomyelitis virus in Leopoldville. Belgian Congo. 2. Studies of the safety and efficacy of vaccination. Bull World Health Organ, 1960, 22, 215-234.
Lebrun A, Cerf J, Gelfand HM, et al. - Vaccination with the CHAT strain of type 1 attenuated poliomyelities virus in Leopoldville, Belgian Congo. 1. Description of the city, its history of poliomyelitis, and the plan of the vaccination campaign. Bull World Health Organ, 1960, 22, 203-213.
Pastoret PP. - Human and animal vaccine contaminations. Biologicals, 2010, 38, 332-334.
Koprowski H, Jervis GA, Norton TW, et al. - Further studies on oral administration of living poliomyelitis virus to human subjects. Proc Soc Exp Biol Med, 1953, 82, 277-280.
Horstmann DM. - The Sabin live poliovirus vaccination trials in the USSR, 1959. Yale J Biol Med, 1991, 64, 499-512.
Poland GA, Jacobson RM. - The age-old struggle against the antivaccinationists. N Engl J Med, 2011, 364, 97-99.
Tebit DM, Arts EJ. - Tracking a century of global expansion and evolution of HIV to drive understanding and to combat disease. Lancet Infect Dis, 2011, 11, 45-56.
Wertheim JO, Worobey M.- Dating the age of the SIV lineages that gave rise to HIV-1 and HIV-2. PLoS Comput Biol, 2009, 5, e1000377.
Korber B, Muldoon M, Theiler J, et al. - Timing the ancestor of the HIV-1 pandemic strains. Science, 2000, 288, 1789-1796. (Pubitemid 30399011)
Lemey P, Pybus OG, Rambaut A, et al. - The molecular population genetics of HIV-1 group O. Genetics, 2004, 167, 1059-1068. (Pubitemid 39045617)
Wain LV, Bailes E, Bibollet-Ruche F, et al. - Adaptation of HIV-1 to its human host. Mol Biol Evol, 2007, 24, 1853-1860. (Pubitemid 47236708)
Alexander L, Illyinskii PO, Lang SM, et al. - Determinants of increased replicative capacity of serially passaged simian immunodeficiency virus with nef deleted in rhesus monkeys. J Virol, 2003, 77, 6823-6835. (Pubitemid 36666876)
Lemey P, Suchard M, Rambaut A. - Reconstructing the initial global spread of a human influenza pandemic: a Bayesian spatial-temporal model for the global spread of H1N1pdm. PLoS Curr, 2009, 1, RRN1031.
Lemey P. - Early spread of HIV-1 M in the DRC. Simian Viruses and Emerging Viruses in Humans. Virology, epidemiology and medical history. International Symposium, Paris, 9-10 June 2010. http://www. simianvirusesandemergingdiseasesinhumans.org/
Hunter M. - Beyond the male-migrant : South Africa's long history of health geography and the contemporary AIDS pandemic. Health Place, 2010, 16, 25-33.
Hayes RJ, Schulz KF, Plummer FA. - The cofactor effect of genital ulcers on the per-exposure risk of HIV transmission in sub-Saharan Africa. J Trop Med Hyg, 1995, 98, 1-8.
Haaland RE, Hawkins PA, Salazar-Gonzalez J, et al.- Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1. PLoS Pathog, 2009, 5, e1000274.
De Sousa JD, Muller V, Lemey P, et al. - High GUD incidence in the early 20 century created a particularly permissive time window for the origin and initial spread of epidemic HIV strains. PLoS One, 2010, 5, e9936.
Weiss HA, Hankins CA, Dickson K.- Male circumcision and risk of HIV infection in women : a systematic review and meta-analysis. Lancet Infect Dis, 2009, 9, 669-677.
Spedener D. - Le traitement des pneumonies des noirs par transfusion de sang des convalescents. Bulletin médical du Katanga, 1924, 1, 234-238.
Marx PA, Alcabes PG, Drucker E.- Serial human passage of simian immunodeficiency virus by unsterile injections and the emergence of epidemic human immunodeficiency virus in Africa. Philos Trans R Soc Lond B Biol Sci, 2001, 356, 911-920. (Pubitemid 32614666)
Pepin J, Lavoie M, Pybus OG, et al. - Risk factors for hepatitis C virus transmission in colonial Cameroon. Clin Infect Dis, 2010, 51, 768-776.
Pepin J, Labbe AC, Mamadou-Yaya F, et al. - Iatrogenic transmission of human T cell lymphotropic virus type 1 and hepatitis C virus through parenteral treatment and chemoprophylaxis of sleeping sickness in colonial Equatorial Africa. Clin Infect Dis, 2010, 51, 777-784.
Pepin J, Labbe AC. - Noble goals, unforeseen consequences: control of tropical diseases in colonial Central Africa and the iatrogenic transmission of blood-borne viruses. Trop Med Int Health, 2008, 13, 744-753. (Pubitemid 351678630)
Steverding D. - The history of African trypanosomiasis. Parasit Vectors, 2008, 1, 3 doi : 10.1186/1756-3305-1-3
Giles-Vernick T. - Apes and Humans in the Sangha Basin 1890-1920. Simian Viruses and Emerging Viruses in Humans . Virology, epidemiology and medical history. International Symposium, Paris, 9-10 June 2010. http://www. simianvirusesandemergingdiseasesinhumans.org/