Cycling or not cycling: cell cycle regulatory molecules and adult neurogenesis.

[en] The adult brain most probably reaches its highest degree of plasticity with the lifelong generation and integration of new neurons in the hippocampus and olfactory system. Neural precursor cells (NPCs) residing both in the subgranular zone of the dentate gyrus and in the subventricular zone of the lateral ventricles continuously generate neurons that populate the dentate gyrus and the olfactory bulb, respectively. The regulation of NPC proliferation in the adult brain has been widely investigated in the past few years. Yet, the intrinsic cell cycle machinery underlying NPC proliferation remains largely unexplored. In this review, we discuss the cell cycle components that are involved in the regulation of NPC proliferation in both neurogenic areas of the adult brain.

Research center :

Giga-Neurosciences - ULiège

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Beukelaers, Pierre ^✱; Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (Bologne)

Vandenbosch, Renaud ^✱

Caron, Nicolas ; Université de Liège - ULiège > GIGA - Neurosciences

Nguyen, Laurent ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Moonen, Gustave ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Malgrange, Brigitte ; Université de Liège - ULiège > GIGA - Neurosciences

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Cycling or not cycling: cell cycle regulatory molecules and adult neurogenesis.

Publication date :

2012

Journal title :

Cellular and Molecular Life Sciences

ISSN :

1420-682X

eISSN :

1420-9071

Publisher :

Birkhäuser, Basel, Switzerland

Volume :

Issue :

Pages :

1493-1503

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Fonds Léon Fredericq [BE]

Available on ORBi :

since 13 November 2011

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