[en] This paper reports on the synthesis and relaxivity properties of tetraacetic DOTA-type chelating agents featuring one or two alkyne groups directly grafted on the tetraaza macrocyclic ring and available for "click" reactions with azide-bearing substrates. The racemic DOTAma ligand bearing one alkyne group was obtained by a bisaminal template route. The same approach was used to prep. ligand DOTAda substituted by two alkyne groups located on two adjacent carbon atoms. The S,S enantiomer of DOTAda was also prepd. by a "crab-like" condensation. This ligand is the first example of a DOTA deriv. featuring two reactive functions adjacent to each other on the macrocyclic ring. A triacetic monoalkyne ligand (DO3ma) was also synthesized for comparison purposes. NMR studies indicate that the Yb(III) chelates of DOTAma and DOTAda adopt two conformations in solns. in which the tetraaza ring is rigidified. The hydration state of the Eu(III) chelates was detd. by luminescence spectroscopy, and the water exchange time of the Gd(III) complexes was measured by 17O NMR. Ring substitution accelerates the water exchange. These data were used to interpret nuclear magnetic relaxation dispersion curves of the Gd(III) chelates. Two long aliph. chains have been added to DOTAda by a "click" procedure to form the (C18)2DOTAda ligand. The corresponding Gd(III) complex forms micelles of unusually high relaxivity presumably because of the close proximity of the aliph. chains on the macrocyclic ring that ensures a rigid double anchoring into the micelles.
Disciplines :
Chemistry
Author, co-author :
Vanasschen, Christian
Bouslimani, Nouri ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie de coordination et radiochimie
Thonon, David ; Université de Liège - ULiège > Centre de recherches du cyclotron
Desreux, Jean-François ; Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences)
Language :
English
Title :
Gadolinium DOTA Chelates Featuring Alkyne Groups Directly Grafted on the Tetraaza Macrocyclic Ring: Synthesis, Relaxation Properties, "Click" Reaction, and High-Relaxivity Micelles
Publication date :
2011
Journal title :
Inorganic Chemistry
ISSN :
0020-1669
eISSN :
1520-510X
Publisher :
American Chemical Society, Washington, United States - District of Columbia
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
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