1 Richards, C. D. (1998) Interleukin-6. In Cytokines (Mire-Sluis, A. and Thorpe, R., eds.), pp. 87-100, Academic Press, San Diego
2 Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C. and Chrousos, G. P.(1998) The pathophysiologic roles of interleukin-6 in human disease. Ann. Int. Med. 128, 127-137
3 Tanabe, O., Akira, S., Kamiya, T., Wong, G. G., Hirano, T. and Kishimoto, T. (1988) Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human. J. Immunol. 141, 3875-3881
4 Ray, A., Sassone-Corsi, P. and Sehgal, P. B. (1989) A multiple cytokine-and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation Mol. Cell. Biol. 9, 5537-5547
5 Akira, S., Isshiki, H., Sugita, T., Tanabe, O., Kinoshita, S., Nishio, Y., Nakajima, T., Hirano, T. and Kishimoto, T. (1990) A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 9, 1897-1906
6 Libermann, T. A. and Baltimore, D. (1990) Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol. Cell. Biol. 10, 2327-2334
7 Ghosh, S., May, M. J. and Kopp, E. B. (1998) NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol 16, 225-260
8 Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T. and Akira, S. (1993) Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc. Natl Acad. Sci. U.S.A. 90, 10193-10197
9 Baumann, H. and Gauldie, J. (1994) The acute phase response. Immunol. Today 15, 74-80
10 Kishimoto, T., Taga, T. and Akira, S. (1994) Cytokine signal transduction. Cell 76, 253-262
11 Ramji, D. P., Vitelli, A., Tronche, F., Cortese, R. and Ciliberto, G. (1993) The two C/EBP isoforms. IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 β. induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucleic Acids Res. 21, 289-294
12 Wang, P., Wu, P., Anthes, J. C., Siegel, M. I., Egan, R. W. and Billah, M. M. (1994) Interleukin-10 inhibits interleukin-8 production in human neutrophils. Blood 83, 2678-2683
13 Vanden Berghe, W., De Bosscher, K., Boone, E., Plaisance, S. and Haegeman, G. (1999) The nuclear factor-κB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter. J. Biol. Chem. 274, 32091-32098
14 Bours, V., Burd, P. R., Brown, K., Villalobos, J., Park, S., Ryseck, R.-P, Bravo, R., Kelly, K. and Siebenlist, U. (1992) A novel mitogen-inducible gene product related to p50/p105-NF-κB participates in transactivation through a κB site. Mol. Cell. Biol. 12, 685-695
15 Chariot, A., Van Lint, C., Chapelier, M., Gielen, J., Merville, M.-P. and Bours, V. (1999) CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein. Oncogene 18, 4007-4014
16 Vanden Berghe, W, Plaisance, S., Boone, E., De Bosscher, K., Schmitz, M., Fiers, W. and Haegeman, G. (1998) p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-κB p65 transactivation mediated by tumor necrosis factor. J. Biol. Chem. 273, 3285-3290
17 Plaisance, S., Vanden Berghe, W., Boone, E., Fiers, W. and Haegeman, G. (1997) Recombination signal sequence binding protein Jκ is constitutively bound to the NF-κB site of the interleukin-6 promoter and acts as a negative regulatory factor. Mol. Cell. Biol. 17, 3733-3743
18 Ito, C. Y., Kazantsev, A. G. and Baldwin, Jr, A. S. (1994) Three NF-κB sites in the lκB-α promoter are required for induction of gene expression by TNF α. Nucleic Acids Res. 22, 3787-3792
19 Arenzana-Seisdedos, F., Thompson, J., Rodriguez, M. S., Bachelerie, F., Thomas, D. and Hay, R. T. (1995) Inducible nuclear expression of newly synthesized 1κB α negatively regulates DNA-binding and transcriptional activities of NF-κB. Mol. Cell. Biol. 15, 2689-2696
20 Dejardin, E., Deregowsky, V., Chapelier, M., Jacobs, N, Gielen, J., Merville, M.-P. and Bours, V. (1999) Regulation of NF-κB activity by lκB-related proteins in adenocarcinoma cells. Oncogene 18, 2567-2577
21 Janknecht, R. and Hunter, T. (1996) Transcription. A growing coactivator network. Nature (London) 383, 22-23
22 Janknecht, R. and Hunter, T. (1996) Versatile molecular glue. Transcriptional control. Curr. Biol. 6, 951-954
23 Zhong, H., Voll, R. E. and Ghosh, S. (1998) Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell 1, 661-671
24 Muraoka, M., Konishi, M., Kikuchi-Yanoshita, R., Tanaka, K., Shitara, N., Chong, J.-M., Iwama, T. and Miyaki, M. (1996) p300 gene alterations in colorectal and gastric carcinomas. Oncogene 12, 1565-1569
25 Elias, J. A. and Lentz, V. (1990) IL-1 and tumor necrosis factor synergistically stimulate libroblast IL-6 production and stabilize IL-6 messenger RNA. J. Immunol. 145, 161-166
26 Mallardo, M., Giordano, V., Dragonetti, E., Scala, G. and Quinto, I. (1994) DNA damaging agents increase the stability of interleukin-1α, interleukin-1β. and interleukin-6 transcripts and the production of the relative proteins. J. Biol. Chem. 269, 14899-14904
27 Rola-Pleszczynski, M. and Stankova, J. (1992) Leukotriene B4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: transcriptional and posttranscriptional mechanisms. Blood 80, 1004-1011
28 Schmitz, M. L., Stelzer. G., Altmann, H., Meisterernst, M and Baeuerle, P. A. (1995) Interaction of the COOH-terminal transactivation domain of p65 NF-κB with TATA-binding protein, transcription factor IIB, and coactivators. J. Biol. Chem. 270, 7219-7226
29 Trecca, D., Guerrini, L., Fracchiolla, N. S., Pomati, M., Baldini, L., Maiolo, A. T. and Neri, A. (1997) Identification of a tumor-associated mutant form of the NF-κB RelA gene with reduced DNA-binding and transactivating activities. Oncogene 14, 791-799
30 Webster, G. A. and Perkins, N. D. (1999) Transcriptional cross talk between NF-κB and p53. Mol. Cell. Biol. 19, 3485-3495
31 Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S.-C., Heyman, R. A., Rose, D. W., Glass, C. K. and Rosenfeld, M. G. (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85, 403-414
32 Parry, G. C. N. and Mackman, N. (1997) Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-κB-mediated transcription. J. Immunol. 159, 5450-5456
33 Rapp, L. and Chen, J. J. (1998) The papillomavirus E6 proteins. Biochim. Biophys. Acta 1378, F1-F19
34 Yang, J.-P., Hori, M., Sanda, T. and Okamoto, T. (1999) Identification of a novel inhibitor of nuclear factor-B, RelA-associated inhibitor J. Biol. Chem. 274, 15662-15670