Article (Scientific journals)
Vers une tritherapie orale dans le traitement pharmacologique du diabete de type 2?
Scheen, André
2005In Revue Médicale de Liège, 60 (5-6), p. 414-8
Peer reviewed
 

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Keywords :
Blood Glucose/metabolism; Cardiovascular Diseases/etiology/prevention & control; Diabetes Mellitus, Type 2/drug therapy; Drug Therapy, Combination; Humans; Hypoglycemic Agents/therapeutic use; Metformin/therapeutic use; Risk Factors; Thiazolidinediones/therapeutic use
Abstract :
[en] Type 2 diabetes is a complex disease combining several disturbances in various organs, especially a defect of insulin secretion by the pancreas, an increased production of glucose by the liver and a reduced insulin-mediated glucose uptake by the skeletal muscle. Each of these abnormalities can be, at least partially, reversed by a specific pharmacological approach, an agent promoting insulin secretion (sulphonylurea, glinide), metformin and a thiazolidinedione (glitazone), respectively. A triple oral therapy with "sulphonylurea (glinide)--metformin--glitazone", targeting simultaneously the three main metabolic abnormalities of type 2 diabetes, deserves special attention. Promising results have been observed in recent clinical trials as far as blood glucose control and some other cardiovascular risk factors are concerned. The precise place of such oral triple therapy remains to be specified, at a late stage to delay the shift to insulin or earlier in the natural history of the disease, to avoid the decline of the number and/or function of beta cells and the resulting metabolic deterioration.
Disciplines :
Pharmacy, pharmacology & toxicology
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
Vers une tritherapie orale dans le traitement pharmacologique du diabete de type 2?
Alternative titles :
[en] Towards a tripple oral therapy in the pharmacological treatment of type 2 diabetes?
Publication date :
2005
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Special issue title :
Le diabète sucré dans tous ses états
Volume :
60
Issue :
5-6
Pages :
414-8
Peer reviewed :
Peer reviewed
Additional URL :
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